Psychopharmacology

, Volume 128, Issue 2, pp 191–197

Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin

  • E. P. M. Prinssen
  • Mark S. Kleven
  • Wouter Koek
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050124

Cite this article as:
Prinssen, E., Kleven, M. & Koek, W. Psychopharmacology (1996) 128: 191. doi:10.1007/s002130050124

Abstract

Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT1A agonists and neuroleptics, and support the hypothesis that combined 5-HT1A agonist/D2-like antagonist properties may be of clinical importance.

Key words SchizophreniaNeurolepticsDopamine D2 receptorSerotonin 5-HT2 receptorα1-AdrenoceptorConditioned avoidance responseRats

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. P. M. Prinssen
    • 1
  • Mark S. Kleven
    • 1
  • Wouter Koek
    • 1
  1. 1.Centre de Recherche Pierre Fabre, 17 ave. Jean Moulin, F-81106 Castres Cedex, FranceFR