Psychopharmacology

, Volume 128, Issue 1, pp 17–20

Acute cocaine effects on absolute cerebral blood flow

  • E. A. Wallace
  • G. Wisniewski
  • G. Zubal
  • C. H. vanDyck
  • S. E. Pfau
  • E. O. Smith
  • M. I. Rosen
  • M. C. Sullivan
  • S. W. Woods
  • T. R. Kosten
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050104

Cite this article as:
Wallace, E., Wisniewski, G., Zubal, G. et al. Psychopharmacology (1996) 128: 17. doi:10.1007/s002130050104

Abstract

Cocaine use has been associated with vasoconstriction and stroke, and several studies have demonstrated that it decreases relative cerebral blood flow (rCBF) in humans. However, rCBF has not been quantitated. We compared 40 mg IV cocaine hydro-chloride to placebo effects on absolute rCBF in four cocaine users using 99mTc-HMPAO SPECT with a modified microsphere model for CBF quantitation. Cocaine produced significant decreases in rCBF in all regions studied with a mean decrease of 30% in absolute whole brain blood flow (P = 0.002) which was 3-fold greater than relative blood flow changes.

Key words CocaineAcute effectsCerebral blood flowHuman

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. A. Wallace
    • 1
  • G. Wisniewski
    • 1
  • G. Zubal
    • 1
  • C. H. vanDyck
    • 1
  • S. E. Pfau
    • 1
  • E. O. Smith
    • 1
  • M. I. Rosen
    • 1
  • M. C. Sullivan
    • 1
  • S. W. Woods
    • 1
  • T. R. Kosten
    • 1
  1. 1.Division of Substance Abuse, Departments of Psychiatry, Diagnostic Radiology and Section of Cardiovascular Medicine, Yale University School of Medicine, Connecticut, USAUS
  2. 2.VA Connecticut, Psychiatry – 116A, 950 Campbell Avenue, West Haven, CT 06516, USAUS