Rapid Communication

Psychopharmacology

, Volume 148, Issue 3, pp 322-324

First online:

Memory disturbances in ”Ecstasy” users are correlated with an altered brain serotonin neurotransmission

  • L. RenemanAffiliated withGraduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
  • , J. BooijAffiliated withGraduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
  • , B. SchmandAffiliated withDepartment of Neurology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
  • , W. van den BrinkAffiliated withAmsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, 1105 BC Amsterdam, The Netherlands
  • , B. GunningAffiliated withDepartment of Child-Adolescent Psychiatry, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Abstract 

Rationale: Methylenedioxymethamphetamine (MDMA) is known to damage brain pre-synaptic serotonin (5-HT) neurons. Since loss of 5-HT neurons has been implicated in memory loss, it is important to establish whether MDMA use may produce changes in postsynaptic 5-HT receptors and memory function in humans. Objectives: To investigate whether MDMA use leads to compensative alterations in post-synaptic 5-HT2A receptors and whether there is a relation with memory disturbances. Methods: Brain cortical 5-HT2A receptor densities were studied with [123I]-5-I-R91150 SPECT in five abstinent MDMA users and nine healthy controls. Memory performance was assessed using RAVLT. Results: [123I]-5-I-R91150 binding ratios were significantly higher in the occipital cortex of MDMA users than in controls, indicating up-regulation. Mean cortical 5-HT2A receptor binding correlated positively with RAVLT-recall in MDMA users. Conclusion: Our preliminary results may indicate altered 5-HT neuronal function with correlated memory impairment in abstinent MDMA users.

Key words MDMA Ecstasy SPECT 5-HT2 receptor Memory