Original Investigation

Psychopharmacology

, Volume 231, Issue 15, pp 3009-3017

First online:

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

  • David ChengAffiliated withNeuroscience Research AustraliaSchool of Medical Sciences, University of New South Wales
  • , Jac Kee LowAffiliated withNeuroscience Research AustraliaSchizophrenia Research Institute
  • , Warren LoggeAffiliated withNeuroscience Research AustraliaSchizophrenia Research Institute
  • , Brett GarnerAffiliated withIllawarra Health and Medical Research Institute, University of WollongongSchool of Biological Sciences, University of Wollongong
  • , Tim KarlAffiliated withNeuroscience Research AustraliaSchool of Medical Sciences, University of New South WalesSchizophrenia Research Institute Email author 

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Abstract

Rationale

Patients suffering from Alzheimer’s disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.

Objectives

The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents.

Materials and methods

Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.

Results

Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.

Conclusions

This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

Keywords

Alzheimer’s disease Novel therapeutic Cannabidiol Transgenic APPswe/PS1∆E9 mice Cognition Behaviour Social recognition memory Object recognition memory