Psychopharmacology

, Volume 231, Issue 15, pp 3009–3017

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

  • David Cheng
  • Jac Kee Low
  • Warren Logge
  • Brett Garner
  • Tim Karl
Original Investigation

DOI: 10.1007/s00213-014-3478-5

Cite this article as:
Cheng, D., Low, J.K., Logge, W. et al. Psychopharmacology (2014) 231: 3009. doi:10.1007/s00213-014-3478-5

Abstract

Rationale

Patients suffering from Alzheimer’s disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.

Objectives

The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents.

Materials and methods

Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.

Results

Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.

Conclusions

This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

Keywords

Alzheimer’s diseaseNovel therapeuticCannabidiolTransgenic APPswe/PS1∆E9 miceCognitionBehaviourSocial recognition memoryObject recognition memory

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • David Cheng
    • 1
    • 2
  • Jac Kee Low
    • 1
    • 3
  • Warren Logge
    • 1
    • 3
  • Brett Garner
    • 4
    • 5
  • Tim Karl
    • 1
    • 2
    • 3
  1. 1.Neuroscience Research AustraliaRandwickAustralia
  2. 2.School of Medical SciencesUniversity of New South WalesKensingtonAustralia
  3. 3.Schizophrenia Research InstituteDarlinghurstAustralia
  4. 4.Illawarra Health and Medical Research InstituteUniversity of WollongongWollongongAustralia
  5. 5.School of Biological SciencesUniversity of WollongongWollongongAustralia