Alcohol attenuates amygdala–frontal connectivity during processing social signals in heavy social drinkers
- Stephanie M. GorkaAffiliated withDepartment of Psychology, University of Illinois–Chicago
- , Daniel A. FitzgeraldAffiliated withDepartment of Psychiatry, University of Illinois–Chicago
- , Andrea C. KingAffiliated withDepartment of Psychiatry and Behavioral Neurosciences, University of Chicago
- , K. Luan PhanAffiliated withDepartment of Psychiatry, University of Illinois–ChicagoJesse Brown VA Medical Center, Mental Health Service Line Email author
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Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol’s effects are likely to extend beyond regional changes in brain activity to changes that manifest on a broader functional circuit level.
The current study examines alcohol’s effects on functional connectivity (i.e., "coupling") between the amygdala and the PFC during the processing of socio-emotional stimuli using functional magnetic resonance imaging (fMRI).
In a randomized, double blind, placebo-controlled, within-subjects cross-over design, 12 heavy, social drinkers performed an fMRI task designed to probe amygdala response to socio-emotional stimuli (angry, fearful, and happy faces) following acute ingestion of alcohol or placebo. Functional connectivity between the amygdala and PFC was examined and compared between alcohol and placebo sessions using a conventional generalized psychophysiological interaction (gPPI) analysis.
Relative to placebo, alcohol reduced functional coupling between the amygdala and the right orbitofrontal cortex (OFC) during processing of both angry and fearful faces. Alcohol also reduced functional coupling between the amygdala and left OFC during processing of happy faces.
These preliminary findings suggest that alcohol’s effects on social behavior may be mediated by alternations in functional connectivity between the amygdala and OFC during processing of emotional faces.
KeywordsAlcohol Amygdala Functional connectivity Social threat
- Alcohol attenuates amygdala–frontal connectivity during processing social signals in heavy social drinkers
Volume 229, Issue 1 , pp 141-154
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- Springer Berlin Heidelberg
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- Functional connectivity
- Social threat
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- Author Affiliations
- 1. Department of Psychology, University of Illinois–Chicago, 1007 West Harrison Street (M/C 285), Chicago, IL, 60657, USA
- 2. Department of Psychiatry, University of Illinois–Chicago, 1747 West Roosevelt Road, Chicago, IL, 60608, USA
- 3. Department of Psychiatry and Behavioral Neurosciences, University of Chicago, 5841 S. Maryland Avenue (MC-3077), Chicago, IL, 60637, USA
- 4. Jesse Brown VA Medical Center, Mental Health Service Line, 820 S. Damen Avenue, Chicago, IL, 60612, USA