Psychopharmacology

, Volume 219, Issue 2, pp 253–270

Measuring impulsivity in mice: the five-choice serial reaction time task

Authors

  • Sandra Sanchez-Roige
    • School of PsychologyUniversity of Sussex
  • Yolanda Peña-Oliver
    • School of PsychologyUniversity of Sussex
    • School of PsychologyUniversity of Sussex
Review

DOI: 10.1007/s00213-011-2560-5

Cite this article as:
Sanchez-Roige, S., Peña-Oliver, Y. & Stephens, D.N. Psychopharmacology (2012) 219: 253. doi:10.1007/s00213-011-2560-5

Abstract

Rationale

Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented.

Objectives

This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity.

Methods

The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms.

Results

Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable.

Conclusions

The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.

Keywords

Five-choice serial reaction time task Impulsivity Attention Task parameters Mice

Copyright information

© Springer-Verlag 2011