Psychopharmacology

, Volume 214, Issue 3, pp 617–624

Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers—a two isotopes SPECT study

  • I Hui Lee
  • Yen Kuang Yang
  • Po See Chen
  • Hui Chun Huang
  • Tzung Lieh Yeh
  • Ru-Band Lu
  • Nan-Tsing Chiu
  • Wei Jen Yao
  • Shih-Hsien Lin
Original Investigation

DOI: 10.1007/s00213-010-2064-8

Cite this article as:
Lee, I.H., Yang, Y.K., Chen, P.S. et al. Psychopharmacology (2011) 214: 617. doi:10.1007/s00213-010-2064-8

Abstract

Rationale and objective

Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability.

Methods

Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [99mTc] TRODAT and [123I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs).

Results

LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT.

Conclusion

Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.

Keywords

Event-related evoked potential (ERP)Loudness dependence auditory evoked potentials (LDAEPs)Dopamine transporterSerotonin transporterSPECT

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • I Hui Lee
    • 1
    • 2
  • Yen Kuang Yang
    • 1
    • 2
    • 4
  • Po See Chen
    • 1
    • 2
    • 5
  • Hui Chun Huang
    • 1
    • 5
  • Tzung Lieh Yeh
    • 1
    • 2
    • 4
  • Ru-Band Lu
    • 1
    • 2
    • 4
  • Nan-Tsing Chiu
    • 3
  • Wei Jen Yao
    • 3
  • Shih-Hsien Lin
    • 2
  1. 1.Department of PsychiatryNational Cheng Kung University HospitalTainanRepublic of China
  2. 2.Department of Psychiatry, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  3. 3.Department of Nuclear Medicine, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  4. 4.Institute of Behavioral Medicine, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  5. 5.Department of PsychiatryNational Cheng Kung University HospitalYunlinRepublic of China