Psychopharmacology

, Volume 211, Issue 1, pp 27–31

Higher dopamine transporter density in Parkinson’s disease patients with depression

  • Andre C. Felicio
  • Tais S. Moriyama
  • Clecio Godeiro-Junior
  • Ming C. Shih
  • Marcelo Q. Hoexter
  • Vanderci Borges
  • Sonia M. A. Silva
  • Edson Amaro-Junior
  • Luiz A. F. Andrade
  • Henrique B. Ferraz
  • Rodrigo A. Bressan
Original Investigation

DOI: 10.1007/s00213-010-1867-y

Cite this article as:
Felicio, A.C., Moriyama, T.S., Godeiro-Junior, C. et al. Psychopharmacology (2010) 211: 27. doi:10.1007/s00213-010-1867-y

Abstract

Rationale

Depression is a frequent non-motor symptom in Parkinson’s disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is not clear since clinical matching was inappropriate and DAT reduction could be attributed to PD severity.

Objectives

To further examine the role of DAT in PD depression, this study compared thoroughly matched depressed vs. non-depressed PD patients (ndPD).

Materials and methods

Twenty PD patients (n = 10 ndPD; n = 10 dPD) matched for age and disease severity were submitted to brain SPECT imaging with [99mTc]-TRODAT-1, a DAT radioligand. DAT-binding potential was calculated using regions of interest bilaterally drawn in the striatum, caudate, and putamen. Depression was defined according to Beck Depression Inventory (BDI; cut-off >18).

Results

Mean BDI scores were higher in dPD (25.0 ± 5.6) than in ndPD patients (8.0 ± 1.9, p < 0.0001). DAT density was greater on dPD especially in the left caudate (dPD 0.87 ± 0.19 vs. ndDP 0.69 ± 0.18, p = 0.02) and right putamen (dPD 0.37 ± 0.07 vs. ndPD 0.28 ± 0.13, p = 0.03) than in ndPD patients.

Conclusion

Our results suggest that in vivo DAT density is increased in dPD patients as compared to ndPD, suggesting that DAT is implicated in the pathophysiology of PD depression.

Keywords

Parkinson’s disease (PD) Depression SPECT Dopamine transporter 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Andre C. Felicio
    • 1
    • 2
    • 3
  • Tais S. Moriyama
    • 1
    • 3
  • Clecio Godeiro-Junior
    • 1
    • 2
  • Ming C. Shih
    • 1
    • 3
  • Marcelo Q. Hoexter
    • 1
    • 3
  • Vanderci Borges
    • 2
  • Sonia M. A. Silva
    • 2
  • Edson Amaro-Junior
    • 1
  • Luiz A. F. Andrade
    • 1
  • Henrique B. Ferraz
    • 2
  • Rodrigo A. Bressan
    • 1
    • 3
  1. 1.Instituto Israelita de Ensino e Pesquisa (IIEP)Hospital Israelita Albert Einstein (HIAE)Sao PauloBrazil
  2. 2.Department of Neurology and NeurosurgeryFederal University of Sao PauloSão PauloBrazil
  3. 3.Laboratório Interdisciplinar de Neurociências Clínicas (LiNC)Federal University of São PauloSao PauloBrazil

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