Psychopharmacology

, Volume 210, Issue 1, pp 1–12

Reinforcing effects of nicotine and non-nicotine components of cigarette smoke

  • Jed E. Rose
  • Al Salley
  • Frederique M. Behm
  • James E. Bates
  • Eric C. Westman
Original Investigation

DOI: 10.1007/s00213-010-1810-2

Cite this article as:
Rose, J.E., Salley, A., Behm, F.M. et al. Psychopharmacology (2010) 210: 1. doi:10.1007/s00213-010-1810-2

Abstract

Rationale

Nicotine and non-nicotine components of cigarette smoke contribute to its reinforcing effects; however, the specific role of each component in maintaining behavior has not yet been elucidated.

Objectives

To assess the reinforcing effects of nicotine and non-nicotine components of cigarette smoke by presenting a concurrent choice paradigm in which participants had access to intravenous (IV) nicotine infusions vs. saline (placebo) infusions and puffs from denicotinized (“denic”) cigarettes vs. air (sham puffs). We also measured the effects on self-administration of prior satiation with each component.

Methods

Sixteen smokers participated in seven sessions: 1) a baseline smoking assessment, used to tailor the nicotine dose per infusion; 2) two sessions for training discrimination of IV nicotine vs. saline infusions and denic smoke vs. sham puffs; and 3) four sessions assessing choice behavior after different satiation conditions.

Results

Denic smoke was self-administered more than any other alternative, including IV nicotine. IV nicotine, however, was preferred over IV saline and sham puffs. Preference for denic smoke vs. IV nicotine was inversely correlated with subjective ratings of “comfort” associated with nicotine. Smoke satiation reduced the number of denic puffs taken during choice periods, while prior nicotine administration did not affect puffing behavior. Smoking withdrawal symptoms were alleviated both by nicotine administration and by denic smoke.

Conclusions

In established smokers, non-nicotine aspects of cigarette smoking have potent reinforcing effects. While current smoking cessation pharmacotherapies primarily address the nicotine component of cigarette addiction, future cessation strategies should also be designed to target non-nicotine factors.

Keywords

Nicotine Addiction Reinforcement Self-administration 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Jed E. Rose
    • 1
    • 3
  • Al Salley
    • 1
  • Frederique M. Behm
    • 1
  • James E. Bates
    • 1
  • Eric C. Westman
    • 2
  1. 1.Department of PsychiatryDuke University Medical CenterDurhamUSA
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA
  3. 3.Center for Nicotine and Smoking Cessation ResearchDuke University Medical CenterDurhamUSA