Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB
- Sudhakar SelvarajAffiliated withUniversity Department of Psychiatry, Warneford HospitalMedical Research Council Cyclotron Unit, Hammersmith Hospital
- , Naga Venkatesha MurthyAffiliated withGSK CIC, Imperial College London
- , Zubin BhagwagarAffiliated withDepartment of Psychiatry, Yale University
- , Subrata K. BoseAffiliated withMedical Research Council Cyclotron Unit, Hammersmith Hospital
- , Rainer HinzAffiliated withWolfson Molecular Imaging Centre, University of Manchester
- , Paul M. GrasbyAffiliated withMedical Research Council Cyclotron Unit, Hammersmith Hospital
- , Philip J. CowenAffiliated withUniversity Department of Psychiatry, Warneford Hospital Email author
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The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls.
This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls.
We studied 5-HTT binding using [11C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls.
The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex.
These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis.
KeywordsSerotonin Serotonin transporter [11C]DASB Depression Mood disorder PET
- Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB
Volume 213, Issue 2-3 , pp 555-562
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- Serotonin transporter
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- Author Affiliations
- 1. University Department of Psychiatry, Warneford Hospital, Oxford, UK
- 2. Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, UK
- 3. GSK CIC, Imperial College London, London, UK
- 4. Department of Psychiatry, Yale University, Newhaven, USA
- 5. Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK