, Volume 197, Issue 4, pp 683-685
Date: 02 Feb 2008

The effect of lamotrigine on platelet serotonin concentration in patients with bipolar depression

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Lamotrigine (3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triazine) is an antiepileptic drug effective in the treatment of bipolar disorder in a depressive phase (Calabrese et al. 1999; Goldsmith et al. 2003) and in the prevention of relapse of bipolar depression (Calabrese et al, 2003). Preclinical studies suggested that the antidepressant effects of lamotrigine might be related to alterations of serotonin (5-hydroxytryptamine, 5-HT) neurotransmission (Consoni et al. 2006; Ahmad et al. 2005). Blood platelets might be used as a peripheral model for some processes (5-HT uptake, 5-HT2 receptors binding, and monoamine oxidase activity) in the central 5-HT synaptosomes (Camacho and Dimsdale 2000). Because there are no data evaluating the effects of lamotrigine on platelet markers in patients, the aim of the study was to determine the effects of 6-week lamotrigine treatment on platelet 5-HT concentration in patients with bipolar I disorder currently depressed (bipolar depression) and to compare ...