Psychopharmacology

, Volume 197, Issue 1, pp 95–105

Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study

Authors

    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • Scott H. Kollins
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • Avery M. Lutz
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • David P. Fitzgerald
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • Desiree W. Murray
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • Christina Redman
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
  • Jed E. Rose
    • Department of Psychiatry and Behavioral SciencesDuke University Medical Center
Original Investigation

DOI: 10.1007/s00213-007-1009-3

Cite this article as:
McClernon, F.J., Kollins, S.H., Lutz, A.M. et al. Psychopharmacology (2008) 197: 95. doi:10.1007/s00213-007-1009-3

Abstract

Rationale

Individuals with attention deficit hyperactivity disorder (ADHD) smoke at higher rates than the general population; however, little is known about the mechanisms underlying this comorbidity.

Objective

This study evaluated the effects of overnight abstinence on withdrawal symptoms and cognitive performance in adult smokers with and without ADHD.

Materials and methods

Individuals smoking ≥15 cigarettes per day were recruited from the community and underwent an evaluation to establish a diagnosis of ADHD (n = 12) or not (n = 14). Withdrawal symptoms, mood, craving, cognitive performance, and smoking cue reactivity were measured during two laboratory sessions—in a ‘Satiated’ condition participants smoked up to and during the session while in an ‘Abstinent’ condition, participants were required to be smoking abstinent overnight and remain abstinent during the session.

Results

The effects of abstinence on ADHD and non-ADHD smokers did not differ for withdrawal symptom severity, mood, craving or cue reactivity. Significant Group × Condition interactions were observed for measures of attention and response inhibition on the Conners’ CPT. For reaction time (RT) variability and errors of commission, the ADHD group exhibited greater decrements in performance after overnight abstinence compared to the non-ADHD group. The effects of abstinence on other cognitive measures (e.g., rapid visual information processing task, cued Go/No-Go task) did not differ between the two groups.

Conclusion

This preliminary study is the first to systematically evaluate the effects of acute smoking abstinence in adult smokers diagnosed with ADHD. Individuals with the disorder may smoke at higher rates due to greater worsening of attention and response inhibition after abstinence.

Keywords

Smoking Withdrawal Attention deficit hyperactivity disorder Nicotine dependence

Copyright information

© Springer-Verlag 2007