Psychopharmacology

, Volume 196, Issue 4, pp 555–564

Improvement of contextual memory by S 24795 in aged mice: comparison with memantine

  • Daniel Beracochea
  • Aurelie Boucard
  • Caryn Trocme-Thibierge
  • Philippe Morain
Original Investigation

DOI: 10.1007/s00213-007-0987-5

Cite this article as:
Beracochea, D., Boucard, A., Trocme-Thibierge, C. et al. Psychopharmacology (2008) 196: 555. doi:10.1007/s00213-007-0987-5

Abstract

Results

In comparison with 5-month-old mice, 18- to 19-month-old mice exhibited a severe and specific memory impairment in a contextual serial discrimination (CSD) task involving the learning and remembering of two successive spatial discriminations carried out on two distinct floors. This impairment was specific, as spatial memory, simultaneously tested on a simple discrimination (SD) task, was not affected in these aged mice. This deficit was completely reversed by 9-day per os administration of S 24795, a partial agonist of α7 nicotinic receptors, at either 0.3 or 1.0 mg/kg. Memantine, an NMDA receptor antagonist, also had a memory-enhancing effect at a dose of 3.0 mg/kg, but not at 0.3 mg/kg.

Conclusions

The memory-enhancing effect of S 24795 was due to a strong enhancement of contextual memory as indicated by a decrease in interference rate, whereas memantine enhanced spatial/semantic memory. S 24795 was more effective than memantine and also appears to be more specific to flexible forms of memory, one of the first cognitive domains (i.e. episodic memory) affected in Alzheimer’s disease.

Keywords

AgeingMiceContextual memoryEpisodic memoryS 24795MemantineNicotinic receptors

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Daniel Beracochea
    • 1
  • Aurelie Boucard
    • 1
  • Caryn Trocme-Thibierge
    • 2
  • Philippe Morain
    • 2
  1. 1.Centre de Neurosciences Intégratives et Cognitives (CNIC), CNRS UMR 5228Universités de Bordeaux 1 et 2Talence-CédexFrance
  2. 2.Institut de Recherches Internationales ServierCourbevoie CedexFrance