Original Investigation

Psychopharmacology

, Volume 195, Issue 1, pp 71-84

First online:

Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis

  • G. BezzinaAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , T. H. C. CheungAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , K. AsgariAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , C. L. HampsonAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , S. BodyAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , C. M. BradshawAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham Email author 
  • , E. SzabadiAffiliated withPsychopharmacology Section, Division of Psychiatry, University of Nottingham
  • , J. F. W. DeakinAffiliated withNeuroscience & Psychiatry Unit, Division of Psychiatry & Behavioural Sciences, University of Manchester
  • , I. M. AndersonAffiliated withNeuroscience & Psychiatry Unit, Division of Psychiatry & Behavioural Sciences, University of Manchester

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Abstract

Rationale

There is evidence that lesions of the nucleus accumbens core (AcbC) promote preference for smaller earlier reinforcers over larger delayed reinforcers in inter-temporal choice paradigms. It is not known whether this reflects an effect of the lesion on the rate of delay discounting, on sensitivity to reinforcer magnitude, or both.

Aim

We examined the effect of AcbC lesions on inter-temporal choice using a quantitative method that allows effects on delay discounting to be distinguished from effects on sensitivity to reinforcer size.

Materials and methods

Sixteen rats received bilateral quinolinic acid-induced lesions of the AcbC; 14 received sham lesions. They were trained under a discrete-trials progressive delay schedule to press two levers (A and B) for a sucrose solution. Responses on A delivered 50 μl of the solution after a delay d A; responses on B delivered 100 μl after d B. d B increased across blocks of trials, while d A was manipulated across phases of the experiment. Indifference delay d B(50) (value of d B corresponding to 50% choice of B) was estimated in each phase, and linear indifference functions (d B(50) vs d A) derived.

Results

dB(50) increased linearly with dA (r2 > 0.95 in each group). The intercept of the indifference function was lower in the lesioned than the sham-lesioned group; slope did not differ between groups. The lesioned rats had extensive neuronal loss in the AcbC.

Conclusions

The results confirm that lesions of the AcbC promote preference for smaller, earlier reinforcers and suggest that this reflects an effect of the lesion on the rate of delay discounting.

Keywords

Quinolinic acid Excitotoxin Lesion Nucleus accumbens Inter-temporal choice Delay of reinforcement Delay discounting Rat