Original Investigation

Psychopharmacology

, Volume 191, Issue 3, pp 587-598

First online:

Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control

  • Tommy PattijAffiliated withDepartment of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU medical center Email author 
  • , Mieke C. W. JanssenAffiliated withDepartment of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU medical center
  • , Louk J. M. J. VanderschurenAffiliated withDepartment of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU medical center
  • , Anton N. M. SchoffelmeerAffiliated withDepartment of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU medical center
  • , Marcel M. van GaalenAffiliated withDepartment of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU medical center

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Rationale

Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D1 and D2 receptors and the nucleus accumbens (Acb) in this respect.

Objective

The present experiments were designed to study the role of dopamine D1 and D2 receptors in the Acb in inhibitory response control.

Methods

Rats were trained in a five-choice serial reaction time task and received bilateral infusions into the Acb core or shell of either SCH 23390 or eticlopride (representing selective dopamine D1 and D2 receptor antagonists, respectively). Subsequently, the effects of systemic amphetamine on inhibitory response control were examined.

Results

Eticlopride into either the Acb core or shell did not affect premature responding, a measure for inhibitory response control, but increased reaction time and errors of omission. In contrast, SCH 23390 into both regions reduced premature responding, slightly improved attentional performance in the core and increased errors of omission in the shell. Amphetamine robustly increased premature responding which was dose-dependently blocked by eticlopride in the Acb core and attenuated by eticlopride in the shell. In addition, amphetamine slightly decreased accuracy and reaction time, and these effects were inhibited by eticlopride in both regions. SCH 23390 infusion into the Acb core or shell did not alter amphetamine’s effects.

Conclusion

Our data provide evidence for the involvement of dopamine D1 and D2 receptors in the Acb core and shell in inhibitory response control and attentional performance.

Keywords

Amphetamine Attention Dopamine D1 receptor Dopamine D2 receptor Eticlopride Inhibitory response control SCH 23390