Psychopharmacology

, Volume 185, Issue 4, pp 441–450

5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice

Authors

  • R. M. M. De Almeida
    • Laboratório de NeurociênciasUniversidade do Vale do Rio dos Sinos, UNISINOS
  • M. M. Rosa
    • Laboratório de NeurociênciasUniversidade do Vale do Rio dos Sinos, UNISINOS
  • D. M. Santos
    • Laboratório de NeurociênciasUniversidade do Vale do Rio dos Sinos, UNISINOS
  • D. M. Saft
    • Laboratório de NeurociênciasUniversidade do Vale do Rio dos Sinos, UNISINOS
  • Q. Benini
    • Laboratório de NeurociênciasUniversidade do Vale do Rio dos Sinos, UNISINOS
    • Department of Psychology, Bacon HallTufts University
    • Department of PsychiatryTufts University
    • Department of PharmacologyTufts University
    • Department of NeuroscienceTufts University
Original Investigation

DOI: 10.1007/s00213-006-0333-3

Cite this article as:
De Almeida, R.M.M., Rosa, M.M., Santos, D.M. et al. Psychopharmacology (2006) 185: 441. doi:10.1007/s00213-006-0333-3

Abstract

Rationale

Systemic injections of 5-HT1B receptor agonists have been shown to have specific anti-aggressive effects in aggressive individuals. One site of action for these drugs is the 5-HT1B receptors in the ventral orbitofrontal cortex (VO PFC), an area that has been implicated in the inhibitory control of behavior and is a terminal region for 5-HT projections.

Objective

To assess the anti-aggressive effects of the 5-HT1B receptor agonist CP-94,253 when microinjected into the VO PFC (0.1, 0.56, and 1.0 μg/0.2 μl) or into the infralimbic prefrontal cortex (IL PFC; 1.0 μg/0.2 μl) in separate groups of aggressive resident male mice. To confirm the 5-HT1B receptor as the critical site of action for the anti-aggressive effects, the 5-HT1B/D antagonist GR-127,935 was microinjected at 10.0 μg/0.2 μl into the VO PFC. After recovery from surgery, the anti-aggressive effects of microinjected CP-94,253 were studied during 5-min resident–intruder confrontations that were recorded and analyzed.

Results

Microinjections of CP-94,253 (0.56 and 1.0 μg/0.2 μl) dose-dependently reduced the frequency of attack bites and sideways threats. This effect was behaviorally specific because non-aggressive motor activities were not significantly altered by the drug. In the IL vmPFC or in an area lateral to the VO PFC, CP-94,253 (1.0 μg/0.2 μl) did not have significant behavioral effects.

Conclusions

The results highlight the 5-HT1B receptors in the VO PFC as a particularly important site for the inhibition of species-typical aggressive behavior in male mice.

Keywords

5-HT receptorsAggressive behaviorMaleMicroinjectionCP-94,253GR-127,935Infralimbic cortexPrefrontal cortex

Copyright information

© Springer-Verlag 2006