Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
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Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use.
The present study tests the hypothesis that the rate of delta-opioid agonist administration greatly contributes to the convulsive properties, but not the antidepressant-like effects, of delta-opioid agonists.
Materials and methods
The delta-opioid agonist SNC80 (1, 3.2, and 10 mg kg−1 or vehicle) was administered to Sprague–Dawley rats by intravenous infusion over different durations of time (20 s, 20, or 60 min). Convulsions were measured by observation prior to determining antidepressant-like effects in the forced swim test.
Slowing the rate of SNC80 administration minimized delta agonist-induced convulsions without altering the effects of SNC80 in the forced swim test.
These data suggest that delta agonist-induced antidepressant properties are independent of convulsive effects, and that it may be possible to eliminate the convulsions produced by delta agonists, further promoting their potential clinical utility.
- Abreu ME, Bigelow GE, Fleisher L, Walsh SL (2001) Effects of intravenous injection speed on responses to cocaine and hydromorphone in humans. Psychopharmacology (Berl) 154:76–84 CrossRef
- Baamonde A, Daugé V, Ruiz-Gayo M, Fulga IG, Turcaud S, Fournié-Zaluski MC, Roques BP (1992) Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid δ and dopamine D1 receptor stimulation. Eur J Pharmacol 216:157–166 CrossRef
- Baird TJ, Deng S-X, Landry DW, Winger G, Woods JH (2000) Natural and artificial enzymes against cocaine. I. Monoclonal antibody 15A10 and the reinforcing effects of cocaine in rats. J Pharmacol Exp Ther 295:1127–1134
- Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002a) Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology 26(6):744–755 CrossRef
- Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002b) Convulsant activity of a nonpeptidic delta-opioid receptor agonist is not required for antidepressant-like effects. Psychopharmacology (Berl) 164(1):42–48 CrossRef
- Broom DC, Nitsche JF, Pintar JE, Rice KC, Woods JH, Traynor JR (2002c) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J Pharmacol Exp Ther 303:723–729 CrossRef
- Comer SD, Hoenicke EM, Sable AI, McNutt RW, Chang KJ, DeCosta BR, Mosberg HI, Woods JH (1993) Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice. J Pharmacol Exp Ther 267(2):888–895
- Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121:66–72 CrossRef
- de Wit H, Dudish S, Ambre J (1993) Subjective and behavioral effects of diazepam depend on its rate of onset. Psychopharmacology (Berl) 112:324–330 CrossRef
- Dykstra LA, Schoenbaum GM, Yarbrough J, McNutt R, Chang K-J (1993) A novel δ-opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J Pharmacol Exp Ther 267:875–882
- Filliol D, Ghozland S, Chluba J, Martin M, Matthes HWD, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL (2000) Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses. Nature 25:195–200
- Greenstein YJ, Pavlides C, Winson J (1998) Long-term potentiation in the dentate gyrus is preferentially induced at theta rhythm periodicity. Brain Res 438:331–334 CrossRef
- Hong EJ, Rice KC, Calderon S, Woods JH, Traynor JR (1998) Convulsive behavior of nonpeptide δ-opioid ligands: comparison of SNC80 and BW373U86 in mice. Analgesia 3:269–276
- Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH (2004) δ-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague–Dawley rats. J Pharmacol Exp Ther 309(1):173–181 CrossRef
- Kollins SH, Rush CR, Pazzaglia, Ali JA (1998) Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate. Exp Clin Psychopharmacol 6(4):367–374 CrossRef
- Larson J, Wong D, Lynch G (1986) Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Res 368:347–350 CrossRef
- Law PY (2004) Delta opioid receptor signal trafficking. In: Chang K-J, Porreca F, Woods JH (eds) The delta receptor. Dekker, New York, pp 61–88
- Negus SS, Butelman ER, Chang K-J, DeCosta B, Winger G, Woods JH (1994) Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys. J Pharmacol Exp Ther 270:1025–1034
- Pakarinen ED, Woods JH, Moerschbaecher JM (1995) Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist. J Pharmacol Exp Ther 272:552–559
- Pollack GM, Shen DD (1985) A timed intravenous pentylenetetrazol infusion seizure model for quantifying the anticonvulsant effect of valproic acid in the rat. J Pharmacol Methods 13:135–146 CrossRef
- Porrino LJ (1993) Functional consequences of acute cocaine treatment depend on route of administration. Psychopharmacology (Berl) 112:343–351 CrossRef
- Samaha A-N, Li Y, Robinson TE (2002) The rate of intravenous cocaine administration determines susceptibility to sensitization. J Neurosci 22(8):3244–3250
- Schetz JA, Calderon SN, Bertha CM, Rice KC, Porreca F (1996) Rapid in vivo metabolism of a methylether derivative of (±)-BW373U86: the metabolic fate of [3H]SNC121 in rats. J Pharmacol Exp Ther 279:1069–1076
- Tejedor-Real P, Micó JA, Smadja C, Maldonado R, Roques BP, Gibert-Rahola J (1998) Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. Eur J Pharmacol 354:1–7 CrossRef
- Tsukada M, Aihara T, Mizuno M, Kato H, Ito K (1994) Temporal pattern sensitivity of long-term potentiation in hippocampal CA1 neurons. Biol Cybern 70:495–503 CrossRef
- Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
Volume 182, Issue 4 , pp 588-596
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