Psychopharmacology

, Volume 182, Issue 4, pp 545–550

Comparison of three nicotine treatments: initial reactions and preferences with guided use

  • Nina G. Schneider
  • Scott Terrace
  • Margaret A. Koury
  • Shilpan Patel
  • Behram Vaghaiwalla
  • Regina Pendergrass
  • Richard E. Olmstead
  • Chris Cortner
Original Investigation

DOI: 10.1007/s00213-005-0123-3

Cite this article as:
Schneider, N.G., Terrace, S., Koury, M.A. et al. Psychopharmacology (2005) 182: 545. doi:10.1007/s00213-005-0123-3

Abstract

Rationale

Misuse or dislike of nicotine replacement treatments (NRTs) undermines their effectiveness. Brief testing among NRTs could allow tailoring by preference to improve outcome.

Objective

To test initial reactions/preferences to NRTs in a single session crossover design with guided use.

Methods

Smokers were offered two doses of three NRTs: gum (2 and 4 mg), inhaler, and nasal spray (NNS) in a 5-h test with proper use enforced. Subjects rated each NRT and ranked among NRTs on use variables and preferences.

Results

Gum was ranked over inhaler and NNS for “ease of use,” “safety” and “prefer in public.” Four-milligram gum was rated higher than 2 mg on several variables. With experience, “ease of use” and “liking” improved for gum. Both inhaler and NNS ranked low on considering “use >3 months” vs gum. Dislike of NRT was reflected in refusal of second doses. For those testing all doses (n=9), inhaler ranked last on “relief of withdrawal,” “choose under stress,” and “choice to help quit.” Craving and withdrawal were relieved over time with any NRT use.

Conclusions

Sampling of treatments can identify reactions key to initial compliance with these NRTs.

Keywords

Nicotine replacement treatmentsPreferencesTailoringNicotine gumNicotine nasal sprayNicotine inhalerPharmacotherapyDependence

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Nina G. Schneider
    • 1
    • 2
  • Scott Terrace
    • 1
    • 2
  • Margaret A. Koury
    • 1
    • 2
  • Shilpan Patel
    • 1
    • 2
  • Behram Vaghaiwalla
    • 1
    • 2
  • Regina Pendergrass
    • 1
    • 2
  • Richard E. Olmstead
    • 1
    • 2
  • Chris Cortner
    • 1
    • 2
  1. 1.Veteran Affairs Greater Los Angeles (VAGLA) Healthcare SystemLos AngelesUSA
  2. 2.Department of Psychiatry and Biobehavioral SciencesUniversity of California (UCLA)Los AngelesUSA