Psychopharmacology

, Volume 168, Issue 3, pp 344–346

Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

Authors

    • University of Muenster
    • Department of PsychiatryUniversity of Muenster
  • Andreas Erfurth
    • University of Muenster
    • Department of PsychiatryUniversity of Muenster
  • Patricia Ohrmann
    • University of Muenster
    • Department of PsychiatryUniversity of Muenster
  • Michael Gössling
    • University of Muenster
    • Department of PsychiatryUniversity of Muenster
    • Department of Clinical RadiologyUniversity of Muenster
  • Volker Arolt
    • University of Muenster
    • Department of PsychiatryUniversity of Muenster
  • Walter Heindel
    • University of Muenster
    • Department of Clinical RadiologyUniversity of Muenster
  • Bettina Pfleiderer
    • University of Muenster
    • Department of Clinical RadiologyUniversity of Muenster
Original Investigation

DOI: 10.1007/s00213-003-1440-z

Cite this article as:
Michael, N., Erfurth, A., Ohrmann, P. et al. Psychopharmacology (2003) 168: 344. doi:10.1007/s00213-003-1440-z

Abstract

Rationale

The dorsolateral prefrontal cortex (DLPFC) participates in the pathophysiology of mania. In particular, left-sided structural and metabolic abnormalities have been described.

Objectives

Clinical symptoms may be due to hyperactivity of cortical glutamatergic neurons, resulting in increased excitatory neurotransmitter flux and thus enhanced Glx levels.

Methods

Glutamate/glutamine (Glx) levels were assessed by proton magnetic resonance spectroscopy (1H-MRS) in eight acute manic patients compared with age- and gender-matched controls.

Results

Manic patients had significantly elevated Glx levels (t-test; t=–3.1, P=0.008) within the left DLPFC.

Conclusions

Our results indicate that the prefrontal cortical glutamatergic system is involved in the pathophysiology of acute mania. This may have implications for the treatment of mania.

Keywords

Acute maniaBipolar disorderGlutamateGlutamineProton magnetic resonance spectroscopy

Copyright information

© Springer-Verlag 2003