Psychopharmacology

, Volume 168, Issue 1, pp 118–123

Effects of SCH 23390 and eticlopride on cocaine-seeking produced by cocaine and WIN 35,428 in rats

Original Investigation

DOI: 10.1007/s00213-002-1276-y

Cite this article as:
Schenk, S. & Gittings, D. Psychopharmacology (2003) 168: 118. doi:10.1007/s00213-002-1276-y
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Abstract

Rationale.

Exposure to a small amount of cocaine can trigger relapse, and so an understanding of the mechanisms underlying cocaine-seeking are important for the development of effective anti-relapse treatments.

Objectives.

The present study sought to compare the contributions of dopamine D1- and D2-like receptors in drug-seeking produced by cocaine and WIN 35,428.

Methods.

Reinstatement of extinguished cocaine self-administration was measured for rats that received injections of cocaine (5.0–20.0 mg/kg) or WIN 35,428 (0.1–1.0 mg/kg) following extinction. Prior to the injection of cocaine or WIN 35,428, rats received an injection of the D1-like antagonist, SCH 23390 (0.001–0.010 mg/kg) or the D2-like antagonist, eticlopride (0.01–0.30 mg/kg). Effects of SCH 23390 (0.01 mg/kg) on cocaine-produced locomotor activation were also measured in separate groups of rats.

Results.

The ability of both cocaine and WIN 35,428 to produce cocaine-seeking was dose-dependent. Within the range of doses tested, SCH 23390 failed significantly to attenuate the ability of either cocaine or WIN 35,428 to reinstate extinguished cocaine self-administration, although cocaine-produced locomotor activation was significantly attenuated by pretreatment with the highest dose of SCH 23390. Eticlopride attenuated both cocaine and WIN 35,428 produced cocaine-seeking but lower doses were required to decrease WIN 35,428-produced cocaine-seeking.

Conclusions.

These results suggest that dopamine D2 mechanisms are involved in cocaine-seeking produced by both cocaine and WIN 35,428. The lower potency of eticlopride in attenuating cocaine-produced cocaine-seeking suggest that cocaine's effects at sites other than the dopamine transporter contribute to its ability to elicit drug-seeking.

Keywords.

Relapse Cocaine-seeking Cocaine WIN 35,429 Dopamine SCH 23390 Eticlopride 

Copyright information

© Springer-Verlag  2003

Authors and Affiliations

  1. 1.School of Psychology, Victoria University of Wellington, P.O. Box 600, Wellington, New ZealandNew Zealand

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