Psychopharmacology

, Volume 164, Issue 2, pp 160–167

Acute effects of baclofen, a γ-aminobutyric acid-B agonist, on laboratory measures of aggressive and escape responses of adult male parolees with and without a history of conduct disorder

  • Don R. Cherek
  • Scott D. Lane
  • Cynthia J. Pietras
  • Jennifer Sharon
  • Joel L. Steinberg
Original Investigation

DOI: 10.1007/s00213-002-1167-2

Cite this article as:
Cherek, D.R., Lane, S.D., Pietras, C.J. et al. Psychopharmacology (2002) 164: 160. doi:10.1007/s00213-002-1167-2

Abstract

Rationale. The possible role of γ-aminobutyric acid (GABA) in human aggression was evaluated by administering baclofen, a GABA-B agonist and comparing the effects on laboratory measures of aggression and escape among subjects with and without a history of conduct disorder.

Methods. Twenty male subjects with a history of criminal behavior participated in experimental sessions, which measured aggressive and escape responses. Ten subjects had a history of childhood conduct disorder (CD+) and ten control subjects had no history of CD. Aggression was measured using the point subtraction aggression paradigm (PSAP), which provides subjects with aggressive, escape, and monetary-reinforced response options.

Results. Acute doses (0.07, 0.14 and 0.28 mg/kg) of baclofen had remarkably different effects on aggressive responses among CD+ subjects relative to control subjects. Aggressive responses of CD+ subjects decreased, while aggressive responses of control subjects increased following baclofen administration. Baclofen decreased escape responses for both CD+ and control subjects. No changes in monetary-reinforced responses were observed, indicative of no central nervous system stimulation or sedation.

Conclusions. The GABA-B agonist baclofen suppressed aggressive responses in subjects with a history of childhood CD, while producing the opposite effect in control subjects. These suggest a possible unique role for GABA in the regulation of aggression in CD+ population.

Aggression Escape Baclofen GABA

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Don R. Cherek
    • 1
  • Scott D. Lane
    • 1
  • Cynthia J. Pietras
    • 1
  • Jennifer Sharon
    • 1
  • Joel L. Steinberg
    • 1
  1. 1.Human Psychopharmacology Laboratory, Department of Psychiatry and Behavioral Science, University of Texas-Houston Health Science Center, 1300 Moursund Street, Houston, TX 77030-3497, USA