Psychopharmacology

, Volume 163, Issue 1, pp 36–41

A comparison of the effects of a β-adrenergic blocker and a benzodiazepine upon the recognition of human facial expressions

  • Andrea Zangara
  • R. Blair
  • Valerie H. Curran
Original Investigation

DOI: 10.1007/s00213-002-1120-4

Cite this article as:
Zangara, A., Blair, R. & Curran, V.H. Psychopharmacology (2002) 163: 36. doi:10.1007/s00213-002-1120-4

Abstract

Rationale. Accumulating evidence from neuropsychological and neuroimaging research suggests that facial expressions are processed by at least partially separable neurocognitive systems. Recent evidence implies that the processing of different facial expressions may also be dissociable pharmacologically by GABAergic and noradrenergic compounds, although no study has directly compared the two types of drugs.

Objective. The present study therefore directly compared the effects of a benzodiazepine with those of a β-adrenergic blocker on the ability to recognise emotional expressions.

Methods. A double-blind, independent group design was used with 45 volunteers to compare the effects of diazepam (15 mg) and metoprolol (50 mg) with matched placebo. Participants were presented with morphed facial expression stimuli and asked to identify which of the six basic emotions (sadness, happiness, anger, disgust, fear and surprise) were portrayed. Control measures of mood, pulse rate and word recall were also taken.

Results. Diazepam selectively impaired participants' ability to recognise expressions of both anger and fear but not other emotional expressions. Errors were mainly mistaking fear for surprise and disgust for anger. Metoprolol did not significantly affect facial expression recognition.

Conclusions. These findings are interpreted as providing further support for the suggestion that there are dissociable systems responsible for processing emotional expressions. The results may have implications for understanding why 'paradoxical' aggression is sometimes elicited by benzodiazepines and for extending our psychological understanding of the anxiolytic effects of these drugs.

Benzodiazepine β-Blocker Emotion Emotional expression Facial expression

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Andrea Zangara
    • 1
  • R. Blair
    • 1
  • Valerie H. Curran
    • 1
  1. 1.Department of Psychology, University College London, Gower Street, London WC1H 6BT, UKUK
  2. 2.Institute of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UKUK
  3. 3.Psychopharmacology Laboratories, Sub-department of Clinical Health Psychology, University College London, Gower Street, London WC1H 6BT, UKUK