Psychopharmacology

, Volume 160, Issue 1, pp 1–8

Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats

  • Hajnalka Németh
  • Hedvig Varga
  • Tamás Farkas
  • Zsolt Kis
  • László Vécsei
  • Szatmár Horváth
  • Krisztina Boda
  • Joachim R. Wolff
  • József Toldi
Original Investigation

DOI: 10.1007/s00213-001-0957-2

Cite this article as:
Németh, H., Varga, H., Farkas, T. et al. Psychopharmacology (2002) 160: 1. doi:10.1007/s00213-001-0957-2

Abstract.

Rationale and objectives: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. Methods: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7–19, participated in water maze testing between postnatal days 90 and 102, and were then studied electrophysiologically. Results: Treatment with MK-801 in such a low dose resulted in a very slight impairment of performance in the water maze task, but not in the visual cue response. Besides the slight learning impairment, the electrophysiological study revealed a reduction in the capacity for plasticity in the primary motor cortex of the treated animals, which was pronounced in the controls. Conclusion: The study demonstrates that even a slight impairment in learning and memory function may be accompanied by a cortical plasticity deficiency that is detectable electrophysiologically.

Spatial learning Water maze MK-801 NMDA receptor Cortical plasticity Evoked potential Primary motor cortex Disinhibition

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Hajnalka Németh
    • 1
  • Hedvig Varga
    • 1
  • Tamás Farkas
    • 1
  • Zsolt Kis
    • 1
  • László Vécsei
    • 2
  • Szatmár Horváth
    • 1
  • Krisztina Boda
    • 3
  • Joachim R. Wolff
    • 4
  • József Toldi
    • 1
  1. 1.Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  2. 2.Department of Neurology, University of Szeged, POB 71, 6701 Szeged, Hungary
  3. 3.Department of Medical Informatics, University of Szeged, Korányi fasor 9, 6720 Szeged, Hungary
  4. 4.Department of Anatomy, University of Göttingen, Kreuzbergring 36, 37075 Göttingen, Germany