Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 365, Issue 6, pp 419–426

DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer

  •  C. Ghelardini
  •  N. Galeotti
  •  F. Gualtieri
  •  M. Romanelli
  •  C. Bucherelli
  •  E. Baldi
  •  A. Bartolini
Original Article

DOI: 10.1007/s00210-002-0577-3

Cite this article as:
Ghelardini, C., Galeotti, N., Gualtieri, F. et al. Naunyn-Schmiedeberg's Arch Pharmacol (2002) 365: 419. doi:10.1007/s00210-002-0577-3

Abstract.

DM235 (sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg–1 i.p.), after intraperitoneal (0.001–0.1 mg kg–1) or oral (0.01–0.1 mg kg–1) administration, as shown by a passive avoidance test in mice. The antiamnesic effect of DM235 was comparable to that of well-known nootropic drugs such as piracetam (30–100 mg kg–1 i.p.), aniracetam (100 mg kg–1 p.o.) or rolipram (30 mg kg–1 p.o.). DM235 also prevented mecamylamine (20 mg kg–1 i.p.)-, baclofen (2 mg kg–1 i.p.)- and clonidine (0.125 mg kg–1 i.p.)-induced amnesia in the same test. In the Morris water maze test with rats, scopolamine (0.8 mg kg–1 i.p.) inhibited the reduction of escape latency in both acquisition and retention/retraining tests. DM235 (0.1 mg kg–1 i.p.), 20 min before each daily acquisition training, prevented the scopolamine-induced memory impairment. DM235 (1 mg kg–1 i.p.) also reduced the duration of pentobarbitone-induced hypnosis in mice without modifying the induction time of hypnosis. At the highest effective doses, the investigated compound neither impaired motor coordination (rota-rod test), nor modified spontaneous motility and inspection activity (Animex and hole board tests).

These results indicate that DM235, a compound structurally related to piracetam, is a novel nootropic endowed with the capability to prevent cognitive deficits at very low doses. Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds.

DM235 Sunifiram Nootropic drugs Piracetam Learning and memory Passive avoidance Morris water maze

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  •  C. Ghelardini
    • 1
  •  N. Galeotti
    • 1
  •  F. Gualtieri
    • 2
  •  M. Romanelli
    • 2
  •  C. Bucherelli
    • 3
  •  E. Baldi
    • 3
  •  A. Bartolini
    • 1
  1. 1.Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy
  2. 2.Department of Pharmaceutical Sciences, University of Florence, Via G. Capponi 6, 50121 Florence, Italy
  3. 3.Department of Physiological Sciences, University of Florence, Viale G.B. Morgagni 63, 50134 Florence, Italy