Archives of Toxicology

, Volume 75, Issue 7, pp 407–409

Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population

  • Neslihan Kocabaş
  • Ali Karakaya
  • Suzanne Cholerton
  • Şemra Şardaş
Short Communication

DOI: 10.1007/s002040100252

Cite this article as:
Kocabaş, N., Karakaya, A., Cholerton, S. et al. Arch Toxicol (2001) 75: 407. doi:10.1007/s002040100252
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Abstract.

Catechol O-methyltransferase (COMT) inactivates neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane-bound COMT, respectively, whereby a G to A transition results in a valine to methionine substitution. Ethnic and inter-individual differences in red blood cell COMT activity have been observed in the different populations studied so far. Since, no information is available on inter-individual variability of COMT genotype in Turkish population, we genotyped 217 healthy, unrelated Turkish individuals. The allelic frequencies of COMT gene in the Turkish population were found to be the same as has been observed in Caucasians, but different from Orientals.

Catechol-O-methyltransferase Genotype Genetic polymorphism Turkish population 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Neslihan Kocabaş
    • 1
  • Ali Karakaya
    • 1
  • Suzanne Cholerton
    • 2
  • Şemra Şardaş
    • 1
  1. 1.Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom-Ankara, Turkey
  2. 2.Department of Pharmacological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle-upon-Tyne, NE2 4HH, UK

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