Archives of Toxicology

, Volume 73, Issue 2, pp 123–126

The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site

Authors

  • Robin M. Black
    • DERA, CBD Porton Down, Salisbury, Wilts, SP4 0JQ, UK e-mail: jmharrison@dera.gov.uk Tel.: 0044 1980 613565; Fax: 0044 1980 613371
  • John M. Harrison
    • DERA, CBD Porton Down, Salisbury, Wilts, SP4 0JQ, UK e-mail: jmharrison@dera.gov.uk Tel.: 0044 1980 613565; Fax: 0044 1980 613371
  • Robert W. Read
    • DERA, CBD Porton Down, Salisbury, Wilts, SP4 0JQ, UK e-mail: jmharrison@dera.gov.uk Tel.: 0044 1980 613565; Fax: 0044 1980 613371
SHORT COMMUNICATION

DOI: 10.1007/s002040050596

Cite this article as:
Black, R., Harrison, J. & Read, R. Arch Toxicol (1999) 73: 123. doi:10.1007/s002040050596

Abstract

Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an important biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.

Key words SarinSomanProtein bindingTyrosine residueBiomarker

Copyright information

© Springer-Verlag Berlin Heidelberg 1999