Archives of Toxicology

, Volume 87, Issue 5, pp 825–833

A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population


DOI: 10.1007/s00204-012-1004-2

Cite this article as:
Ma, L., Zhu, L., Gu, D. et al. Arch Toxicol (2013) 87: 825. doi:10.1007/s00204-012-1004-2


MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigated whether rs2910164 is associated with the risk of colorectal cancer (CRC) in a Chinese population. We genotyped the rs2910164 polymorphism using TaqMan method and evaluated the association with CRC risk in a case–control study, including 1,147 CRC patients and 1,203 cancer-free controls. Logistic regression models were used to assess the genetic effects on the development of CRC. Overall, we found that rs2910164 was significantly associated with the reduced CRC risk [GC/CC versus GG: adjusted odds ratio (OR) = 0.78, 95 % confidence intervals (CIs) = 0.66–0.93]. In the stratification analysis, this decreased risk was also pronounced among non-smokers (0.75, 0.61–0.93), non-drinkers (0.77, 0.63–0.94), and no family history of cancer (0.79, 0.65–0.95). Furthermore, GC/CC genotypes were associated with reduced CRC susceptibility in intermediate differentiated CRC (0.75, 0.62–0.90), and similar effect was observed in patients with the advanced stage tumor (Dukes C and D) (0.76, 0.61–0.93). In conclusion, our results suggest that miR-146a rs2910164 may contribute to the susceptibility to CRC in a Chinese population. Further larger population-based prospective and functional studies are needed to validate our findings.


miR-146aPolymorphismColorectal cancerGenetic susceptibility

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Lan Ma
    • 1
    • 2
  • Lingjun Zhu
    • 3
  • Dongying Gu
    • 4
  • Haiyan Chu
    • 2
  • Na Tong
    • 2
  • Jinfei Chen
    • 4
  • Zhengdong Zhang
    • 2
  • Meilin Wang
    • 1
    • 2
  1. 1.Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public HealthNanjing Medical UniversityNanjingChina
  2. 2.Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public HealthNanjing Medical UniversityNanjingChina
  3. 3.Department of OncologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  4. 4.Department of Oncology, Nanjing First HospitalNanjing Medical UniversityNanjingChina