Archives of Toxicology

, Volume 81, Issue 4, pp 299–307

Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure

  • Frédéric Anselme
  • Stéphane Loriot
  • Jean-Paul Henry
  • Frédéric Dionnet
  • Jean-Gérard Napoleoni
  • Christian Thuillez
  • Jean-Paul Morin
Organ Toxicity and Mechanisms

DOI: 10.1007/s00204-006-0147-4

Cite this article as:
Anselme, F., Loriot, S., Henry, JP. et al. Arch Toxicol (2007) 81: 299. doi:10.1007/s00204-006-0147-4

Abstract

Both increase in cardiac arrhythmia incidence and decrease in heart rate variability (HRV) have been described following human and experimental animal exposures to air pollutants. However, the potential causal relationship between these two factors remains unclear. Incidence of ventricular arrhythmia and HRV were evaluated during and after a 3 h period of Diesel engine exhaust exposure in ten healthy and ten chronic ischemic heart failure (CHF, 3 months after coronary ligation) Wistar rats using implantable ECG telemetry. Air pollutants were delivered to specifically designed whole body individual exposure chambers at particulate matter concentrations similar to those measured inside cabins of cars inserted in congested urban traffic. Recordings were obtained from unrestraint and unsedated vigil rats. Immediate decrease in RMSSD was observed in both healthy (6.64 ± 2.62 vs. 4.89 ± 1.67 ms, P < 0.05) and CHF rats (8.01 ± 0.89 vs. 6.6 ± 1.37 ms, P < 0.05) following exposure. An immediate 200–500% increase in ventricular premature beats was observed in CHF rats only. Whereas HRV progressively returned to baseline values within 2.5 h after exposure start, the proarrhythmic effect persisted as late as 5 h after exposure termination in CHF rats. Persistence of ventricular proarrhythmic effects after HRV normalization suggests that HRV reduction is not the mechanism of cardiac arrhythmias in this model. Our methodological approach, closely reflecting the real clinical situations, appeared to be a unique tool to provide further insight into the pathophysiological mechanisms of traffic related airborne pollution health impact.

Keywords

Chronic heart failure Heart rate variability Arrhythmia ECG telemetry Diesel engine emissions Inhalation toxicology 

List of abbreviations

CHF

Chronic heart failure (at least 3 months after left coronary artery ligation)

ECG

Electrocardiogram

HRV

Heart rate variability

RMSSD

The square root of the mean squared differences of successive sinusal beats

SDNN

Standard deviation of sinusal beat-to-beat intervals

SMPS

Scanning mobility particle sizer (apparatus measuring particle number and size distribution)

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Frédéric Anselme
    • 1
  • Stéphane Loriot
    • 2
  • Jean-Paul Henry
    • 2
  • Frédéric Dionnet
    • 3
  • Jean-Gérard Napoleoni
    • 4
  • Christian Thuillez
    • 2
  • Jean-Paul Morin
    • 2
  1. 1.Service de CardiologieRouen University HospitalRouenFrance
  2. 2.INSERM U644, School of Medicine-PharmacyUniversity of Rouen FranceRouen, CedexFrance
  3. 3.Centre d’Etudes et de Recherches Technologiques en Aérothermique et MoteursSaint Etienne du RouvrayFrance
  4. 4.EMKA TechnologiesParisFrance

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