Archives of Toxicology

, Volume 80, Issue 4, pp 212–216

Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions

  • Berta Brodsky
  • Sheetal Trivedi
  • Shyamal Peddada
  • Norris Flagler
  • Uri Wormser
  • Abraham Nyska
Organ Toxicity and Mechanisms

DOI: 10.1007/s00204-005-0032-6

Cite this article as:
Brodsky, B., Trivedi, S., Peddada, S. et al. Arch Toxicol (2006) 80: 212. doi:10.1007/s00204-005-0032-6

Abstract

Sulfur mustard (SM) is powerful alkylator and highly cytotoxic blisterogen in both humans and animals. This study in male guinea pigs shows that, at an early stage (5 h) after SM exposure, a marked increase occurred in epithelial nuclear vacuolation, epidermal thickening, and dermal acute inflammation. Topical iodine treatment reduced the severity of these parameters. The rate of DNA synthesis expressed by incorporation of bromodeoxyuridine was reduced upon topical treatment with iodine only or SM only by 46 and 72%, respectively. Iodine treatment following SM exposure exerted an effect similar to that of SM only, indicating that DNA synthesis is not directly involved in the mechanism of action of iodine-induced protection.

Keywords

Sulfur mustard Skin lesions Iodine DNA synthesis 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Berta Brodsky
    • 1
  • Sheetal Trivedi
    • 2
  • Shyamal Peddada
    • 3
  • Norris Flagler
    • 2
  • Uri Wormser
    • 1
  • Abraham Nyska
    • 2
  1. 1.Department of Pharmacology, School of Pharmacy, Institute of Life SciencesThe Hebrew University of Jerusalem Givat Ram, JerusalemIsrael
  2. 2.Laboratory of Experimental PathologyNational Institute of Environmental Health SciencesResearch Triangle ParkUSA
  3. 3.Biostatistics BranchNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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