Archives of Microbiology

, Volume 192, Issue 8, pp 603–617

Molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus strains for clinical medicine

  • Paulina Nastaly
  • Mariusz Grinholc
  • Krzysztof P. Bielawski
Mini-Review

DOI: 10.1007/s00203-010-0594-4

Cite this article as:
Nastaly, P., Grinholc, M. & Bielawski, K.P. Arch Microbiol (2010) 192: 603. doi:10.1007/s00203-010-0594-4

Abstract

Infections caused by methicillin-resistant S. aureus strains are mainly associated with a hospital setting. However, nowadays, the MRSA infections of non-hospitalized patients are observed more frequently. In order to distinguish them from hospital-associated methicillin-resistant S. aureus (HA-MRSA) strains, given them the name of community-associated methicillin-resistant S. aureus (CA-MRSA). CA-MRSA strains most commonly cause skin infections, but may lead to more severe diseases, and consequently the patient’s death. The molecular markers of CA-MRSA strains are the presence of accessory gene regulator (agr) of group I or III, staphylococcal cassette chromosome mec (SCCmec) type IV, V or VII and genes encoding for Panton–Valentine leukocidin (PVL). In addition, CA-MRSA strains show resistance to β-lactam antibiotics. Studies on the genetic elements of CA-MRSA strains have a key role in the unambiguous identification of strains, monitoring of infections, improving the treatment, work on new antimicrobial agents and understanding the evolution of these pathogens.

Keywords

Accessory gene regulator CA-MRSA Epidemiology Panton–Valentine leukocidin Staphylococcal cassette chromosome mec Virulence 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Paulina Nastaly
    • 1
  • Mariusz Grinholc
    • 1
  • Krzysztof P. Bielawski
    • 1
  1. 1.Laboratory of Molecular Diagnostics, Department of Biotechnology, Intercollegiate Faculty of BiotechnologyUniversity of Gdansk and Medical University of GdanskGdanskPoland

Personalised recommendations