Archives of Microbiology

, Volume 192, Issue 2, pp 85–95

How do bacteria sense and respond to low temperature?


DOI: 10.1007/s00203-009-0539-y

Cite this article as:
Shivaji, S. & Prakash, J.S.S. Arch Microbiol (2010) 192: 85. doi:10.1007/s00203-009-0539-y


Rigidification of the membrane appears to be the primary signal perceived by a bacterium when exposed to low temperature. The perception and transduction of the signal then occurs through a two-component signal transduction pathway consisting of a membrane-associated sensor and a cytoplasmic response regulator and as a consequence a set of cold-regulated genes are activated. In addition, changes in DNA topology due to change in temperature may also trigger cold-responsive mechanisms. Inducible proteins thus accumulated repair the damage caused by cold stress. For example, the fluidity of the rigidified membrane is restored by altering the levels of saturated and unsaturated fatty acids, by altering the fatty acid chain length, by changing the proportion of cis to trans fatty acids and by changing the proportion of anteiso to iso fatty acids. Bacteria could also achieve membrane fluidity changes by altering the protein content of the membrane and by altering the levels of the type of carotenoids synthesized. Changes in RNA secondary structure, changes in translation and alteration in protein conformation could also act as temperature sensors. This review highlights the various strategies by which bacteria senses low temperature signal and as to how it responds to the change.


Cold adaptationBacteriaDesaturasesFatty acid synthesisTwo-component signal transduction pathwayDNA supercoiling


Carbon regulation

The preferred carbon source prevents the simultaneous utilization of alternative carbon sources

Core enzyme

Core enzyme of RNA polymerase (α2ββ′-subunits)


Extracytosolic function

General stress response

A stress response induced by a set of diverse environmental stimuli


General stress proteins

LPXTG motif

Amino acid motif for sortase anchoring

Partner switching

Formation of alternative protein complexes that is controlled by protein phosphorylation


Sigma factor of general stress response of E. coli and other Gram-negative bacteria


Regulator of sigmaB


SigB-dependent general stress response

Specific stress/starvation response

Induced by only one stimulus, adaptation against this stimulus only

Vegetative dormancy

A quiescent metabolic state of vegetative cells

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Centre for Cellular and Molecular BiologyHyderabadIndia
  2. 2.Department of Plant Sciences, School of Life SciencesUniversity of HyderabadHyderabadIndia