, Volume 185, Issue 1, pp 23-27
Date: 10 Jan 2006

The DD-carboxypeptidase activity encoded by pbp4B is not essential for the cell growth of Escherichia coli

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The gene (pbp4B) encoding a putative DD-carboxypeptidase has been deleted in Escherichia coli and it is shown to be not essential for cell division. Disruption of the gene in a genetic background where all putative activities of DD-carboxypeptidases and/or DD-endopeptidases had been eliminated indicates that these activities are not required for cell growth in enterobacteria. The penicillin-binding capacity and a low DD-carboxypeptidase activity of PBP4B are demonstrated.