, Volume 184, Issue 6, pp 425-427
Date: 01 Dec 2005

Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis

Abstract

The cell envelopes of actinomycetes contain lipidated macroamphiphiles, of which the most extensively characterised are the lipoarabinomannans of mycobacteria and related bacteria. We have investigated the mycolic acid-containing actinomycete Gordonia bronchialis and identified the presence of a lipoarabinomannan-like lipoglycan. The extraction and purification procedures recovered a second amphiphilic fraction with properties suggesting a phosphatidylinositol mannoside, consistent with studies of other Gordonia species.

Dedicated to the memory of our former colleague Dr. David Bendell.