Archives of Microbiology

, Volume 184, Issue 2, pp 137–140

Expression of the UGA4 gene encoding the δ-aminolevulinic and γ-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems

  • Mariana Bermudez Moretti
  • Ana Mercedes Perullini
  • Alcira Batlle
  • Susana Correa Garcia
Short Communication

DOI: 10.1007/s00203-005-0022-3

Cite this article as:
Bermudez Moretti, M., Perullini, A.M., Batlle, A. et al. Arch Microbiol (2005) 184: 137. doi:10.1007/s00203-005-0022-3

Abstract

In yeasts, several sensing systems localized to the plasma membrane which transduce information regarding the availability and quality of nitrogen and carbon sources and work in parallel with the intracellular nutrient-sensing systems, regulate the expression and activity of proteins involved in nutrient uptake and utilization. The aim of this work was to establish whether the cellular signals triggered by amino acids modify the expression of the UGA4 gene which encodes the δ-aminolevulinic (ALA) and γ-aminobutyric (GABA) acids permease. In the present paper, we demonstrate that extracellular amino acids regulate UGA4 expression and that this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).

Keywords

Saccharomyces cerevisiaeGene expressionUGA4 geneSensor systems

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Mariana Bermudez Moretti
    • 1
    • 2
    • 4
  • Ana Mercedes Perullini
    • 3
  • Alcira Batlle
    • 3
  • Susana Correa Garcia
    • 1
    • 2
  1. 1.Departamento de Química Biológica (FCEyN, UBA)Ciudad UniversitariaBuenos AiresArgentina
  2. 2.Departamento de Fisiología y Biología Molecular y Celular (FCEyN, UBA)Ciudad UniversitariaBuenos AiresArgentina
  3. 3.Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Depto. Química Biológica (FCEyN, UBA)Ciudad UniversitariaBuenos AiresArgentina
  4. 4. Buenos AiresArgentina