Osteoporosis International

, Volume 12, Issue 6, pp 438–444

Standardization of Bone Mineral Density at Femoral Neck, Trochanter and Ward’s Triangle

  • Y. Lu
  • T. Fuerst
  • S. Hui
  • H. K. Genant
Original Article

DOI: 10.1007/s001980170087

Cite this article as:
Lu, Y., Fuerst, T., Hui, S. et al. Osteoporos Int (2001) 12: 438. doi:10.1007/s001980170087

Abstract:

The International Committee for Standards in Bone Measurement (ICSBM) has published standardization formulas for total hip bone mineral density (BMD). In many applications, however, BMD of hip subregions, such as femoral neck (FN), trochanter (TR), and Ward’s triangle (WT), are commonly measured. This paper addresses whether the standardization formulas for total hip BMD can be adequately used for hip subregions. We used data from 100 healthy women, from 20 to 80 years old, who had hip BMD measured in both the total hip and hip subregions by a Hologic QDR 2000, a Lunar DPX, and a Norland XR26 Mark II. The same women were used by ICSBM for the standardization of total hip BMD. In addition, we used data of 3139 patients from a clinical trial to validate our results. We derived standardization formulas for FN, TR, and WT using the same statistical method as that used for total hip BMD. We applied both total hip calibration formulas and subregion-specific formulas to the data and compared the corresponding effect. We found that the total hip calibration formulas can partially reduce BMD differences between the Hologic and Lunar as well as the Lunar and Norland scanners in hip subregions, but increase differences between the Hologic and Norland scanners. The subregion calibration formulas are most appropriate for calibrating subregion BMD values and their absolute changes, and should be adopted. Standardization is unnecessary for BMD percentage changes in our clinical trial data.

Key words:ANOVA – BMD standardization – DXA – Femur BMD 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2001

Authors and Affiliations

  • Y. Lu
    • 1
  • T. Fuerst
    • 2
  • S. Hui
    • 3
  • H. K. Genant
    • 1
  1. 1.Osteoporosis and Arthritis Research Group, Department of Radiology, University of CaliforniaUS
  2. 2.Synarc Inc., San FranciscoUS
  3. 3.The Regenstrief Institute for Health Care, Indiana University Medical Center, Indianapolis, USAUS

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