Osteoporosis International

, Volume 12, Issue 9, pp 749–754

Bone Metabolism and Gonad Function in Male Patients Undergoing Liver Transplantation: A Two-Year Longitudinal Study

  • A. Floreani
  • A. Mega
  • L. Tizian
  • P. Burra
  • P. Boccagni
  • V. Baldo
  • S. Fagiuoli
  • R. Naccarato
  • G. Luisetto
Original Article

DOI: 10.1007/s001980170051

Cite this article as:
Floreani, A., Mega, A., Tizian, L. et al. Osteoporos Int (2001) 12: 749. doi:10.1007/s001980170051

Abstract

Osteodystrophy is a major complication of end-stage liver disease, especially in postmenopausal women. Our aim in this study was to evaluate bone metabolism and gonad function in men undergoing orthotopic liver transplantation (OLTx). Twenty-three consecutive men (mean age 48 ± 13 years) evaluated for OLTx were studied, assessing the following parameters at baseline and 3, 6, 12 and 24 months after OLTx: lumbar spine (L2–L4) bone mineral density (BMD), parathyroid hormone (PTH), osteocalcin (BGP), 25-hydroxyvitamin D (25OHD), free testosterone (FT) and gonadotropins (FSH, LH). At baseline, 12 patients (52%) had a T-score <–2.5 SD and the mean BMD was 0.806 ± 0.11 g/cm2 (range 0.470–1.045 g/cm2). The BMD was lower 3 months after OLTx and significantly higher 12 and 24 months after OLTx. A significant increase in serum BGP was observed at 6, 12 (p<0.05) and 24 months (p<0.005) after OLTx. The mean serum PTH level was 26.6 ± 3.1 pg/ml at baseline and increased significantly at 12 and 24 months (to 49.4 ± 9.9 and 61.2 ± 10.1 pg/ml, respectively; p<0.05). 25OHD serum levels were low at baseline and returned to the normal range after 12 and 24 months (baseline, 8.73 ± 1.54 ng/ml; 12 months, 16.4 ± 2.6 ng/ml; 24 months, 17.67 ± 3.1 ng/ml; p<0.05). FT was significantly lower at baseline than in a group of 10 healthy controls (5.09 ± 10.99, vs 10.3 ± 1.1 pg/ml; p<0.0001). After OLTx a significant increase in FT was recorded at 6, 12 (p<0.05) and 24 months (p<0.005). FT was not correlated with BMD, however. After OLTx an increase in FSH and LH was observed (but failed to reach statistical significance) at 3 and 6 months, followed by a slight reduction at 12 and 24 months. Thus a high proportion of men with end-stage liver disease do have osteoporosis. After OLTx, an early recovery of gonad function is observed, followed by an increase in bone mass, which occurs from the sixth month onward.

Key words:Bone metabolism – Gonad function – Liver transplantation – Osteoporosis 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2001

Authors and Affiliations

  • A. Floreani
    • 1
  • A. Mega
    • 1
  • L. Tizian
    • 2
  • P. Burra
    • 1
  • P. Boccagni
    • 1
  • V. Baldo
    • 3
  • S. Fagiuoli
    • 1
  • R. Naccarato
    • 1
  • G. Luisetto
    • 2
  1. 1.Department of Surgical and Gastroenterological SciencesIT
  2. 2.Department of Medical and Surgical SciencesIT
  3. 3.Department of Hygiene, University of Padua, Padua, ItalyIT

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