Osteoporosis International

, Volume 12, Issue 11, pp 903–908

The Influence of Osteoporotic Fractures on Health-Related Quality of Life in Community-Dwelling Men and Women across Canada

  • J. D. Adachi
  • G. Ioannidis
  • C. Berger
  • L. Joseph
  • A. Papaioannou
  • L. Pickard
  • E. A. Papadimitropoulos
  • W. Hopman
  • S. Poliquin
  • J. C. Prior
  • D. A. Hanley
  • W. P. Olszynski
  • T.  Anastassiades
  • J. P. Brown
  • T. Murray
  • S. A. Jackson
  • A. Tenenhouse
  • and the Canadian Multicentre Osteoporosis Study (CaMos) Research Group
Original Article

DOI: 10.1007/s001980170017

Cite this article as:
Adachi, J., Ioannidis, G., Berger, C. et al. Osteoporos Int (2001) 12: 903. doi:10.1007/s001980170017

Abstract:

Health-related quality of life (HRQL) was examined in relation to prevalent fractures in 4816 community-dwelling Canadian men and women 50 years and older participating in the Canadian Multicentre Osteoporosis Study (CaMos). Fractures were of three categories: clinically recognized main fractures, subclinical vertebral fractures and fractures at other sites. Main fractures were divided and analyzed at the hip, spine, wrist/forearm, pelvis and rib sites. Baseline assessments of anthropometric data, medical history, therapeutic drug use, spinal radiographs and prevalent fractures were obtained from all participants. The SF-36 instrument was used as a tool to measure HRQL. A total of 652 (13.5%) main fractures were reported. Results indicated that hip, spine, wrist/forearm, pelvis and rib fractures had occurred in 78 (1.6%), 40 (0.8%), 390 (8.1%), 19 (0.4%) and 125 (2.6%) individuals, respectively (subjects may have had more than one main fracture). Subjects who had experienced a main prevalent fracture had lower HRQL scores compared with non-fractured participants. The largest differences were observed in the physical functioning (−4.0; 95% confidence intervals (CI): −6.0, −2.0) and role-physical functioning domains (−5.8; 95% CI: −9.5, −2.2). In women, the physical functioning domain was most influenced by hip (−14.9%; 95% CI: −20.9, −9.0) and pelvis (−18.1; 95% CI: −27.6, −8.6) fractures. In men, the role-physical domain was most affected by hip fractures (−35.7; 95% CI: −60.4, −11.1). Subjects who experienced subclinical vertebral fractures had lower HRQL scores than those without prevalent fractures. In conclusion, HRQL was lower in the physical functioning domain in women and the role-physical domain in men who sustained main fractures at the hip. Subclinical vertebral fractures exerted a moderate effect on HRQL.

Key words:Hip – Osteoporosis – Pelvis and rib fractures – Quality of life – SF-36 – Vertebral – Wrist/forearm

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2001

Authors and Affiliations

  • J. D. Adachi
    • 1
  • G. Ioannidis
    • 1
  • C. Berger
    • 2
  • L. Joseph
    • 2
  • A. Papaioannou
    • 1
  • L. Pickard
    • 1
  • E. A. Papadimitropoulos
    • 3
  • W. Hopman
    • 4
  • S. Poliquin
    • 5
  • J. C. Prior
    • 6
  • D. A. Hanley
    • 7
  • W. P. Olszynski
    • 8
  • T.  Anastassiades
    • 9
  • J. P. Brown
    • 10
  • T. Murray
    • 11
  • S. A. Jackson
    • 12
  • A. Tenenhouse
    • 5
  • and the Canadian Multicentre Osteoporosis Study (CaMos) Research Group
  1. 1.Department of Medicine, St Joseph’s Hospital, McMaster University, Hamilton, OntarioCA
  2. 2.CaMos Analysis Centre, McGill University, Montreal, QuebecCA
  3. 3.Eli Lilly, Toronto, OntarioCA
  4. 4.MacKenzie Health Services Research Group, Queen’s University, Kingston, OntarioCA
  5. 5.CaMos National Coordinating Centre, McGill University, Montreal, QuebecCA
  6. 6.Department of Medicine/Endocrinology, University of British Columbia, Vancouver, British ColumbiaCA
  7. 7.Department of Medicine, University of Calgary, Calgary, AlbertaCA
  8. 8.Department of Medicine, University of Saskatchewan, Saskatoon, SaskatchewanCA
  9. 9.Division of Rheumatology, Queen’s University, Kingston, OntarioCA
  10. 10.Centre Hospitalier de l’Universite´ Laval, Ste-Foy, QuebecCA
  11. 11.Department of Medicine, St Michael’s Hospital, Toronto, Ontario;CA
  12. 12.Department of Medicine, University of Alberta, Edmonton, CanadaCA