Osteoporosis International

, Volume 11, Issue 6, pp 493–498

Longitudinal Study of Bone Loss in Pre- and Perimenopausal Women: Evidence for Bone Loss in Perimenopausal Women

  • R. D. Chapurlat
  • P. Garnero
  • E. Sornay-Rendu
  • M. E. Arlot
  • B. Claustrat
  • P. D. Delmas
Original Article

DOI: 10.1007/s001980070091

Cite this article as:
Chapurlat, R., Garnero, P., Sornay-Rendu, E. et al. Osteoporos Int (2000) 11: 493. doi:10.1007/s001980070091

Abstract:

Bone loss before and around the time of menopause is not well characterized by longitudinal studies. We measured bone mineral density at various skeletal sites – total body, femoral neck, trochanter, anteroposterior (AP) and lateral spine, and forearm – with dual-energy X-ray absorptiometry in a large prospective cohort of 272 untreated pre- and perimenopausal women aged 31–59 years, at 1 year intervals for 3 years. Sex steroids and the following markers of bone remodeling were measured: serum osteocalcin (OC), procollagen I carboxyterminal extension peptide, bone alkaline phosphatase (BAP) and urinary crosslinks (CTX and NTX). Seventy-six women were classified as perimenopausal and 196 as premenopausal. Over the 3 years, premenopausal women had no significant bone loss at any site and a small but significant increase in bone mineral density at the trochanter, total hip, AP spine and radius. Perimenopausal women significantly lost bone from cancellous and cortical sites, i.e., the femoral neck, trochanter and lumbar spine. In perimenopausal women with increased follicle stimulating hormone, the rate of bone loss at the femoral neck correlated negatively with OC and BAP. In perimenopausal women, serum estradiol levels decreased during the 3 years of follow-up and bone loss from the trochanter and the AP spine was correlated with serum estradiol after 3 years. In conclusion, among premenopausal women there is no bone loss. In contrast, there is a rapid and diffuse bone loss in perimenopausal women, related to decreased estrogen secretion. Bone markers may be useful to identify these women losing bone.

Key words:Bone loss – DXA – Markers – Perimenopause – Premenopause

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2000

Authors and Affiliations

  • R. D. Chapurlat
    • 1
  • P. Garnero
    • 1
  • E. Sornay-Rendu
    • 1
  • M. E. Arlot
    • 1
  • B. Claustrat
    • 2
  • P. D. Delmas
    • 1
  1. 1.Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 403, Hôpital Edouard Herriot, LyonFR
  2. 2.Laboratoire de Radioanalyse, Hôpital Louis Pradel, Bron, FranceFR