Osteoporosis International

, Volume 9, Issue 4, pp 307–311

Association of Bone Dimensions with a Parathyroid Hormone Gene Polymorphism in Women

  • G. Gong
  • M. L. Johnson
  • M. J. Barger-Lux
  • R. P. Heaney
Original Article

DOI: 10.1007/s001980050152

Cite this article as:
Gong, G., Johnson, M., Barger-Lux, M. et al. Osteoporos Int (1999) 9: 307. doi:10.1007/s001980050152

Abstract:

We have recently shown that bone radiogrammetric dimensions are associated with vitamin D receptor gene polymorphism. Since parathyroid hormone (PTH) plays a central role in maintaining calcium homeostasis and in bone remodeling, we investigated whether bone radiogrammetric dimensions are associated with a PTH gene polymorphism in 91 healthy Caucasian women, who were premenopausal at entry into the study. These women had assessments of bone by radiogrammetry every five years for a median period of 20 years (range 4–27). DNA was extracted from white blood cells. A segment of the PTH gene with a polymorphism at a BstBI restriction site was amplified by polymerase chain reaction. Diameter, cortical thickness and cross-sectional area at standard sites of the metacarpals, radius and femur were measured with radiogrammetry. Higher metacarpal diameter and cross-sectional cortical area, and a slower decrease in radial cortical area with age, were associated with the absence of the BstBI restriction site of the PTH gene. PTH gene polymorphism accounts for about 7–9% of the total variances of bone dimensional variables. These findings suggest that the dimensions of long bones are influenced by allelic variations in the PTH gene or in genes nearby.

Key words:Bone – Metacarpal – Parathyroid hormone – Radiogrammetry – Radius 
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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 1999

Authors and Affiliations

  • G. Gong
    • 1
  • M. L. Johnson
    • 1
  • M. J. Barger-Lux
    • 1
  • R. P. Heaney
    • 1
  1. 1.Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska, USAUS

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