Osteoporosis International

, Volume 25, Issue 3, pp 1181–1185

Diffuse osteosclerosis in a patient with prostate cancer

  • N. Üstün
  • I. Üstün
  • T. Özgür
  • N. Atci
  • F. Aydoğan
  • A. T. Sümbül
  • A. D. Turhanoğlu
Case Report

DOI: 10.1007/s00198-013-2545-9

Cite this article as:
Üstün, N., Üstün, I., Özgür, T. et al. Osteoporos Int (2014) 25: 1181. doi:10.1007/s00198-013-2545-9

Abstract

A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.

Keywords

Bone mineral density Osteoblastic bone metastasis Prostate cancer 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2013

Authors and Affiliations

  • N. Üstün
    • 1
  • I. Üstün
    • 2
  • T. Özgür
    • 3
  • N. Atci
    • 4
  • F. Aydoğan
    • 5
  • A. T. Sümbül
    • 6
  • A. D. Turhanoğlu
    • 1
  1. 1.Department of Physical Medicine and RehabilitationFaculty of Medicine, Mustafa Kemal UniversityHatayTurkey
  2. 2.Department of Internal MedicineMustafa Kemal UniversityHatayTurkey
  3. 3.Department of PathologyMustafa Kemal UniversityHatayTurkey
  4. 4.Department of RadiologyMustafa Kemal UniversityHatayTurkey
  5. 5.Department of Nuclear MedicineMustafa Kemal UniversityHatayTurkey
  6. 6.Department of OncologyMustafa Kemal UniversityHatayTurkey

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