Osteoporosis International

, Volume 24, Issue 10, pp 2681–2691

Diagnostic measures for sarcopenia and bone mineral density

  • A. Y. Bijlsma
  • M. C. G. Meskers
  • M. Molendijk
  • R. G. J. Westendorp
  • S. Sipilä
  • L. Stenroth
  • E. Sillanpää
  • J. S. McPhee
  • D. A. Jones
  • M. Narici
  • H. Gapeyeva
  • M. Pääsuke
  • E. Seppet
  • T. Voit
  • Y. Barnouin
  • J. Y. Hogrel
  • G. Butler-Browne
  • A. B. Maier
Original Article

DOI: 10.1007/s00198-013-2376-8

Cite this article as:
Bijlsma, A.Y., Meskers, M.C.G., Molendijk, M. et al. Osteoporos Int (2013) 24: 2681. doi:10.1007/s00198-013-2376-8

Abstract

Summary

Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.

Introduction

Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.

Methods

In the European cross-sectional study MYOAGE, 178 young (18–30 years) and 274 healthy old participants (69–81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height2), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.

Results

Lean mass and ALM/height2 were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.

Conclusions

The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.

Keywords

AgingBody compositionBone mineral densityMuscleSarcopenia

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2013

Authors and Affiliations

  • A. Y. Bijlsma
    • 1
    • 2
  • M. C. G. Meskers
    • 3
  • M. Molendijk
    • 2
  • R. G. J. Westendorp
    • 2
  • S. Sipilä
    • 4
  • L. Stenroth
    • 4
    • 5
  • E. Sillanpää
    • 4
  • J. S. McPhee
    • 6
  • D. A. Jones
    • 6
  • M. Narici
    • 6
    • 7
  • H. Gapeyeva
    • 8
  • M. Pääsuke
    • 8
  • E. Seppet
    • 9
  • T. Voit
    • 10
  • Y. Barnouin
    • 10
  • J. Y. Hogrel
    • 10
  • G. Butler-Browne
    • 10
  • A. B. Maier
    • 1
    • 2
  1. 1.Department of Internal Medicine, Section of Gerontology and GeriatricsVU University Medical CenterAmsterdamThe Netherlands
  2. 2.Department of Gerontology and GeriatricsLeiden University Medical CentreLeidenThe Netherlands
  3. 3.Department of Rehabilitation MedicineLeiden University Medical CentreLeidenThe Netherlands
  4. 4.Gerontology Research Center and Department of Health SciencesUniversity of JyväskyläJyväskyläFinland
  5. 5.Department of Biology of Physical ActivityUniversity of JyväskyläJyväskyläFinland
  6. 6.School of Healthcare ScienceManchester Metropolitan UniversityManchesterUK
  7. 7.School of Graduate Entry to Medicine and Health, Division of Clinical PhysiologyUniversity of NottinghamDerbyUK
  8. 8.Institute of Exercise Biology and PhysiotherapyUniversity of TartuTartuEstonia
  9. 9.Faculty of Medicine, Institute of BiomedicineUniversity of TartuTartuEstonia
  10. 10.Institute of Myology, GH Pitié-Salpêtrière, UPMC UM 76, INSERM U 974, CNRS UMR 7215ParisFrance