, Volume 24, Issue 3 Supplement, pp 443-478
Date: 11 Jun 2013

Seventh Meeting on Bone Quality 2012: Bone–Fat Interactions

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Bone–fat interactions: the cold facts about marrow adiposity

Casey R. Doucette1, Clifford J. Rosen1

1Maine Medical Center Research Institute

Scarborough, Maine 04074

Email: Doucette: Doucec4@mmc.org

Email: crofen@gmail.com

Abstract The relationship between bone and fat mass is complex. We examined two inbred strains of mice with phenotypic differences in marrow adiposity and bone mass. C3H/HeJ mice, with high bone mass and greater marrow fat, showed increases in gene expression for markers of brown-like adipocytes (Pgc1α, Ucp1) in their bone marrow compared to low basal levels in C57BL/6J mice. Mice with high bone mass may need a marrow thermogenic program to enhance osteogenesis.

Keywords Marrow · Adiposity · Thermogenesis · Osteoblasts


As the obesity epidemic continues to expand, attention has focused on the relationship between increased adiposity and bone mass. Several lines of evidence from epidemiologic studies demonstrate that fat tissue can influence skeletal function in di ...

The publication of the Seventh Meeting on Bone Quality 2012 has been made possible by an educational grant from Servier.