Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?
- M. Di PietroAffiliated withDepartment of Public Health and Infectious Diseases, “Sapienza” University
- , G. SchiavoniAffiliated withDepartment of Public Health and Infectious Diseases, “Sapienza” University
- , V. SessaAffiliated withDepartment of Orthopaedics, San Giovanni Calibita-Fatebenefratelli Hospital
- , F. PallottaAffiliated withDepartment of General Surgery, San Camillo Forlanini Hospital
- , G. CostanzoAffiliated withDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, “Sapienza” University
- , R. SessaAffiliated withDepartment of Public Health and Infectious Diseases, “Sapienza” University Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
We found an association between the presence of Chlamydia pneumoniae DNA both in osteoporotic bone tissue and peripheral blood mononuclear cells (PBMCs) and the increase in circulating resorptive cytokines.
Our study was designed to determine whether C. pneumoniae infection may be involved in osteoporosis-associated bone loss.
The study included 59 women undergoing hip joint replacement surgery for femoral neck fracture: 32 with osteoporosis and 27 with osteoarthritis. A total of 118 tissue specimens (59 bone tissues, 59 PBMCs) were examined for C. pneumoniae DNA by real-time polymerase chain reaction (PCR). Serum levels of soluble receptor activator of nuclear factor kappa B ligand (sRANKL), osteoprotegerin (OPG), interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 were also measured.
C. pneumoniae DNA was detected in osteoporotic bone tissue whereas it was not found in non-osteoporotic bone tissue (p < 0.05). A significantly higher rate of C. pneumoniae DNA (p < 0.05) was found in PBMCs of osteoporotic patients than in those of osteoarthritis patients. Among osteoporotic patients, serum sRANKL, IL-1, and IL-6 concentrations as well as sRANKL/OPG ratio significantly differ between patients with bone tissue and PBMCs positive to C. pneumoniae and C. pneumoniae-negative patients.
The association between the presence of C. pneumoniae DNA, both in bone tissue and PBMCs, and the increase in sRANKL/OPG ratio as well as in IL-1β and IL-6 levels observed in osteoporotic patients suggests C. pneumoniae infection as a new risk factor for osteoporosis.
KeywordsC. pneumoniae Osteoporosis sRANKL/OPG IL-6 IL-1 TNF-α
- Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?
Volume 24, Issue 5 , pp 1677-1682
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- C. pneumoniae
- Industry Sectors
- Author Affiliations
- 1. Department of Public Health and Infectious Diseases, “Sapienza” University, P.le Aldo Moro 5, 00185, Rome, Italy
- 2. Department of Orthopaedics, San Giovanni Calibita-Fatebenefratelli Hospital, Isola Tiberina,, Rome, Italy
- 3. Department of General Surgery, San Camillo Forlanini Hospital, Rome, Italy
- 4. Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, “Sapienza” University, Rome, Italy