Osteoporosis International

, Volume 23, Supplement 8, pp 841–846

Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

Bone Quality Seminars: Subchondral Bone

DOI: 10.1007/s00198-012-2161-0

Cite this article as:
Mahjoub, M., Berenbaum, F. & Houard, X. Osteoporos Int (2012) 23(Suppl 8): 841. doi:10.1007/s00198-012-2161-0


Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.


Hypertrophic chondrocytes Osteoarthritis Subchondral bone Vascular channels 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  1. 1.UR4 “Ageing, Stress and Inflammation”Université Pierre et Marie CurieParis Cedex 5France
  2. 2.Department of RheumatologyAP-HP Saint-Antoine HospitalParisFrance

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