Osteoporosis International

, Volume 24, Issue 2, pp 707–711

Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea: results from the National Claim Registry

  • Y.-K. Lee
  • Y.-C. Ha
  • C. Park
  • J. J. Yoo
  • C. S. Shin
  • K.-H. Koo
Original Article

DOI: 10.1007/s00198-012-2016-8

Cite this article as:
Lee, Y., Ha, Y., Park, C. et al. Osteoporos Int (2013) 24: 707. doi:10.1007/s00198-012-2016-8

Abstract

Summary

We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the Health Insurance Review and Assessment Service (HIRA).

Introduction

Recently, atypical hip fractures in the subtrochanteric region have been reported among patients on bisphosphonate. However, the association between atypical hip fracture and bisphosphonate is controversial. We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the HIRA.

Methods

All new visits or admissions to clinics or hospitals for a typical and atypical hip fractures were recorded nationwide by HIRA using the ICD-10 code classification. Typical and atypical hip fractures were defined as femoral neck/intertrochanteric and subtrochanteric fracture, respectively. Bisphosphonate prescription data were also abstracted from the HIRA database.

Results

The absolute number of typical and atypical hip fracture increased during the study period. Although age-adjusted incidence rates of typical hip fractures were stable in men and women, those of atypical hip fractures increased in women. Nationally, the annual numbers of prescriptions of bisphosphonate also increased during the study period.

Conclusions

The results of this study suggest a possible causal relationship between bisphosphonate use and the increased incidence of atypical hip fracture in Korea.

Keywords

BisphosphonateEpidemiologic studyHip fractureNationwide databaseSubtrochanteric fracture

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  • Y.-K. Lee
    • 1
  • Y.-C. Ha
    • 2
  • C. Park
    • 3
  • J. J. Yoo
    • 4
  • C. S. Shin
    • 5
  • K.-H. Koo
    • 1
  1. 1.Department of Orthopaedic SurgerySeoul National University Bundang HospitalSeongnam-siSouth Korea
  2. 2.Department of Orthopaedic SurgeryChung-Ang University College of MedicineSeoulSouth Korea
  3. 3.Health Insurance Review and Assessment ServiceSeoulSouth Korea
  4. 4.Department of Orthopedic SurgerySeoul National University College of Medicine, Seoul National University HospitalSeoulSouth Korea
  5. 5.Division of Endocrinology and Metabolism, Department of Internal MedicineSeoul National University College of MedicineSeoulSouth Korea