Osteoporosis International

, Volume 24, Issue 2, pp 605–612

Significant inverse relationship between serum undercarboxylated osteocalcin and glycemic control in maintenance hemodialysis patients

  • S. Okuno
  • E. Ishimura
  • N. Tsuboniwa
  • K. Norimine
  • K. Yamakawa
  • T. Yamakawa
  • S. Shoji
  • K. Mori
  • Y. Nishizawa
  • M. Inaba
Original Article

DOI: 10.1007/s00198-012-2003-0

Cite this article as:
Okuno, S., Ishimura, E., Tsuboniwa, N. et al. Osteoporos Int (2013) 24: 605. doi:10.1007/s00198-012-2003-0
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Abstract

Summary

Increased levels of serum undercarboxylated osteocalcin, which were associated with bone metabolism markers, correlated inversely with indices of glucose metabolism (plasma glucose, hemoglobin A1C, and glycated albumin) in hemodialysis patients with abnormalities of bone metabolism.

Introduction

Undercarboxylated osteocalcin (ucOC), a possible marker of bone metabolism and one of the osteoblast-specific secreted proteins, has recently been reported to be associated with glucose metabolism. We tested the hypothesis that ucOC levels are associated with indices of glucose metabolism in chronic hemodialysis patients with abnormalities of bone metabolism.

Methods

Serum ucOC, bone alkaline phosphatase (BAP, a bone formation marker), and tartrate-resistant acid phosphatase-5b (TRACP-5b, a bone resorption marker) were measured in 189 maintenance hemodialysis patients (96 diabetics and 93 non-diabetics), and their relationships with glucose metabolism were examined.

Results

ucOC correlated positively with BAP (ρ = 0.489, p < 0.0001), TRACP-5b (ρ = 0.585, p < 0.0001) and intact parathyroid hormone (iPTH; ρ = 0.621, p < 0.0001). Serum ucOC levels in the diabetic patients were lower than those of non-diabetic patients (p < 0.001), although there were no significant differences in serum BAP or TRACP-5b between diabetic and non-diabetic patients. Serum ucOC correlated negatively with plasma glucose (ρ = −0.303, p < 0.0001), hemoglobin A1C (ρ = −0.214, p < 0.01), and glycated albumin (ρ = −0.271, p < 0.001), although serum BAP or TRACP-5b did not. In multiple linear regression analysis, log [plasma glucose], log [hemoglobin A1C], and log [glycated albumin] were associated significantly with log [ucOC] after adjustment for age, gender, hemodialysis duration, and body mass index but were not associated with log [BAP], log [TRACP-5b], or log [intact PTH].

Conclusion

Increased levels of serum ucOC, which were associated with bone metabolism markers, were inversely associated with indices of glucose metabolism in hemodialysis patients.

Keywords

Bone turnover Diabetes Glycemic control Undercarboxylated osteocalcin 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  • S. Okuno
    • 1
  • E. Ishimura
    • 2
  • N. Tsuboniwa
    • 1
  • K. Norimine
    • 1
  • K. Yamakawa
    • 1
  • T. Yamakawa
    • 1
  • S. Shoji
    • 1
  • K. Mori
    • 3
  • Y. Nishizawa
    • 3
  • M. Inaba
    • 3
  1. 1.Kidney CenterShirasagi HospitalOsakaJapan
  2. 2.Department of NephrologyOsaka City University Graduate School of MedicineOsakaJapan
  3. 3.Department of Metabolism, Endocrinology and Molecular MedicineOsaka City University Graduate School of MedicineOsakaJapan

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