Osteoporosis International

, Volume 22, Issue 6, pp 2017–2021

Strategies for improving the efficacy of bioengineered bone constructs: a perspective

  • H. Petite
  • K. Vandamme
  • L. Monfoulet
  • D. Logeart-Avramoglou
Bone Quality Seminars: Bone Fracture Healing and Strengthening

DOI: 10.1007/s00198-011-1614-1

Cite this article as:
Petite, H., Vandamme, K., Monfoulet, L. et al. Osteoporos Int (2011) 22: 2017. doi:10.1007/s00198-011-1614-1
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Abstract

Bioengineered bone scaffolds are intended for use in large bone defects. Successful bone constructs should stimulate and support both the onset and the continuance of bone ingrowth. In an attempt to improve their performance and to compete with the one of autologous bone grafts, a growing symbiosis at the biological and material level is required. Recent advances have been made to further exploit the osteogenic potential of MSCs in scaffold development. Current research encompasses new strategies for reducing cell death after implantation and the manufacturing of tailored, instructive scaffolds.

Keywords

BoneBone repairCell survivalCoralMesenchymal stem cellsScaffolds

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2011

Authors and Affiliations

  • H. Petite
    • 1
  • K. Vandamme
    • 1
  • L. Monfoulet
    • 1
  • D. Logeart-Avramoglou
    • 1
  1. 1.Laboratoire de Bioingénierie et Biomatériaux Ostéo-Articulaires–UMR CNRS 7052ParisFrance