Osteoporosis International

, Volume 23, Issue 3, pp 1177–1182

Low calcidiol levels and risk of progression of aortic calcification

  • M. Naves-Díaz
  • I. Cabezas-Rodríguez
  • S. Barrio-Vázquez
  • E. Fernández
  • J. B. Díaz-López
  • J. B. Cannata-Andía
Short Communication

DOI: 10.1007/s00198-011-1550-0

Cite this article as:
Naves-Díaz, M., Cabezas-Rodríguez, I., Barrio-Vázquez, S. et al. Osteoporos Int (2012) 23: 1177. doi:10.1007/s00198-011-1550-0

Abstract

Summary

In this observational study, we found a positive relationship between low calcidiol levels and the risk of aortic calcification progression. A 10-ng/mL increase of calcidiol was associated with a decrease in the risk of progression by 44%. This figure was higher than that observed if we increased age by 10 years.

Introduction

The aim of this study was to investigate the relationship between serum calcidiol levels and the onset and progression of aortic calcifications in a community-based sample of ambulatory subjects.

Methods

Three hundred two men and women aged 50 and over underwent two lateral X-rays and were followed up for 4 years. Abdominal aortic calcifications were classified as absent, mild–moderate, and severe. The biochemical measurements of serum calcium, phosphorus, parathyroid hormone, total alkaline phosphatase, tartrate-resistant acid phosphatase, creatinine, calcidiol, calcitriol, and osteocalcin were determined. Subjects who had received anti-osteoporotic treatments were excluded from the analysis.

Results

Subjects with progression of aortic calcifications had significantly lower serum calcidiol levels than those without progression. In the multivariate analysis, using the agreed upon serum levels for calcidiol (>30 ng/mL) as the reference, those subjects with calcidiol levels between 10 and 20 ng/mL showed a higher risk of progression of aortic calcification (odds ratio (OR) = 3.95; 95% confidence interval (CI) = 1.16 to 13.40). An even higher OR was observed in subjects with calcidiol values <10 ng/mL (OR = 4.10; 95% CI = 1.12 to 14.99). In addition, an increase by 1 ng/mL in osteocalcin levels was associated with a 17% reduction of the risk of aortic calcification progression.

Conclusions

An increase by 10 ng/mL of calcidiol was associated with a decrease in the risk of aortic calcifications progression by 44%. This figure was even higher than that observed if we increased age by 10 years. Levels of calcidiol higher than 30 ng/mL seem to be desirable to reduce the progression of aortic calcification and to maintain bone turnover.

Keywords

Aortic calcificationCalcidiol levelsOsteocalcinProgression of vascular calcifications

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2011

Authors and Affiliations

  • M. Naves-Díaz
    • 1
    • 3
  • I. Cabezas-Rodríguez
    • 1
    • 3
  • S. Barrio-Vázquez
    • 1
    • 3
  • E. Fernández
    • 2
    • 3
  • J. B. Díaz-López
    • 1
    • 3
  • J. B. Cannata-Andía
    • 1
    • 3
  1. 1.Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofía de InvestigaciónUniversidad de OviedoOviedoSpain
  2. 2.Laboratorio de Nefrología ExperimentalHospital Universitari Arnau de Vilanova, IRBLLEIDALleidaSpain
  3. 3.REDinREN del ISCIIIOviedoSpain