Osteoporosis International

, Volume 22, Issue 9, pp 2421–2437

Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study

  • K. Bleicher
  • R. G. Cumming
  • V. Naganathan
  • M. J. Seibel
  • P. N. Sambrook
  • F. M. Blyth
  • D. G. Le Couteur
  • D. J. Handelsman
  • H. M. Creasey
  • L. M. Waite
Original Article

DOI: 10.1007/s00198-010-1478-9

Cite this article as:
Bleicher, K., Cumming, R.G., Naganathan, V. et al. Osteoporos Int (2011) 22: 2421. doi:10.1007/s00198-010-1478-9

Abstract

Summary

Aging alone is not the only factor accounting for poor bone health in older men. There are modifiable factors and lifestyle choices that may influence bone health and result in higher bone density and lower fracture risk even in very old men.

Introduction

The aim of this cross-sectional analysis was to identify the factors associated with areal bone mineral density (BMD) and their relative contribution in older men.

Methods

The Concord Health and Ageing in Men Project is a population-based study in Sydney, Australia, involving 1,705 men aged 70–97. Data were collected using questionnaires and clinical assessments. BMD of the hip and spine was measured by dual X-ray absorptiometry.

Results

In multivariate regression models, BMD of the hip was associated with body weight and bone loading physical activities, but not independently with age. The positive relationship between higher BMD and recreational activities is attenuated with age. Factors independently associated with lower BMD at the hip were inability to stand from sitting, a history of kidney stones, thyroxine use, and Asian birth and at the spine, chronic obstructive pulmonary disease, paternal fracture history, and thyroxine use. Higher body weight, participation in dancing, tennis or jogging, quadriceps strength, alcohol consumption, and statin use were associated with higher hip BMD, while older age, osteoarthritis, higher body weight, and aspirin use were associated with higher spinal BMD.

Conclusion

Maintaining body weight, physical activity, and strength were positively associated with BMD even in very elderly men. Other parameters were also found to influence BMD, and once these were included in multivariate analysis, age was no longer associated with BMD. This suggests that age-related diseases, lifestyle choices, and medications influence BMD rather than age per se.

Keywords

AgingBone mineral densityExerciseMenPopulation studiesRisk factors

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2010

Authors and Affiliations

  • K. Bleicher
    • 1
  • R. G. Cumming
    • 1
  • V. Naganathan
    • 2
  • M. J. Seibel
    • 3
  • P. N. Sambrook
    • 4
  • F. M. Blyth
    • 2
  • D. G. Le Couteur
    • 2
  • D. J. Handelsman
    • 2
  • H. M. Creasey
    • 2
  • L. M. Waite
    • 2
  1. 1.School of Public HealthUniversity of SydneySydneyAustralia
  2. 2.Centre for Education and Research on Ageing, Concord HospitalUniversity of SydneyConcordAustralia
  3. 3.ANZAC Research InstituteBone Research ProgramConcordAustralia
  4. 4.Royal North Shore Hospital, Institute of Bone and Joint ResearchUniversity of SydneySydneyAustralia