Osteoporosis International

, Volume 21, Issue 12, pp 1969–1980

Effect of whole-body vibration on BMD: a systematic review and meta-analysis

  • L. Slatkovska
  • S. M. H. Alibhai
  • J. Beyene
  • A. M. Cheung
Review

DOI: 10.1007/s00198-010-1228-z

Cite this article as:
Slatkovska, L., Alibhai, S.M.H., Beyene, J. et al. Osteoporos Int (2010) 21: 1969. doi:10.1007/s00198-010-1228-z
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Abstract

Summary

Our systematic review and meta-analysis of randomized controlled trials (RCTs) examining whole-body vibration (WBV) effect on bone mineral density (BMD) found significant but small improvements in hip areal BMD (aBMD) in postmenopausal women and in tibia and spine volumetric BMD in children/adolescents, but not in other BMD measurements in postmenopausal women and young adults.

Introduction

Animal experiments report anabolic bone changes in response to WBV, but data in humans are limited. Our objective is to conduct a systematic review and meta-analysis of RCTs examining WBV effect on BMD.

Methods

Eligible RCTs included randomized or quasi-randomized trials, with follow-up of ≥6 months, examining WBV effects on BMD in ambulatory individuals without secondary causes of osteoporosis. The weighted mean differences between WBV and control groups in absolute pre-post change in spine and hip aBMD, and in spine and tibia trabecular volumetric BMD (vBMD) were calculated.

Results

Eight RCTs in postmenopausal women (five RCTs), young adults (one RCT), and children and adolescents (two RCTs) were included. The regimens were heterogeneous, study durations were relatively short, and available data was mostly per-protocol. In postmenopausal women, WBV was found to significantly increase hip aBMD (0.015 g cm−2; 95% confidence interval (CI), 0.008–0.022; n = 131) versus controls, but not spine aBMD (n = 181) or tibia trabecular vBMD (n = 29). In young adults, WBV did not increase spine or hip bone mineral content, or tibia trabecular vBMD (n = 53). In children and adolescents, WBV significantly increased spine (6.2 mg cm−3; 95% CI, 2.5–10.0; n = 65) and tibia (14.2 mg cm−3; 95% CI, 5.2–23.2; n = 17) trabecular vBMD.

Conclusions

We found significant but small improvements in BMD in postmenopausal women and children and adolescents, but not in young adults. WBV is a promising new modality, but before recommendations can be made for clinical practice, large-scale long-term studies are needed to determine optimal magnitude, frequency, and duration.

Keywords

Bone mineral density Meta-analysis Quantitative computed tomography Whole-body vibration 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2010

Authors and Affiliations

  • L. Slatkovska
    • 1
    • 2
    • 5
  • S. M. H. Alibhai
    • 1
    • 3
    • 4
    • 5
  • J. Beyene
    • 8
  • A. M. Cheung
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  1. 1.Osteoporosis ProgramUniversity Health Network/Mount Sinai HospitalTorontoCanada
  2. 2.Women’s Health ProgramUniversity Health NetworkTorontoCanada
  3. 3.Department of MedicineUniversity of TorontoTorontoCanada
  4. 4.Department of Health Policy, Management and EvaluationUniversity of TorontoTorontoCanada
  5. 5.Institute of Medical ScienceUniversity of TorontoTorontoCanada
  6. 6.Centre of Excellence in Skeletal Health AssessmentUniversity of TorontoTorontoCanada
  7. 7.Dalla Lana School of Public HealthUniversity of TorontoTorontoCanada
  8. 8.Department of Clinical Epidemiology and BiostatisticsMcMaster UniversityHamiltonCanada

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